Primary percutaneous coronary intervention (PPCI) is the gold standard of treatment of ST segment elevation myocardial infarction (STEMI).Slow flow / no-reflow phenomenon following PPCI in STEMI patients has been a serious and common complication that closely related to the incidence of major adverse cardiovascular events (MACE) and affected patients' prognosis. No reflow is a multi-factorial phenomenon. And its preventive and therapeutic effects are not satisfactory. This prospective randomized controlled study aimed to compare favorable effects of Nitroprusside versus Tirofiban on the prevention of slow flow / no-reflow phenomenon during PPCI.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
1,000
Intracoronary infusion 50\~100μg each time (repeated)
Intracoronary infusion 10μg/kg for single time
Intracoronary infusion 2ml for single time
Anyang District Hospital
Anyang, Henan, China
RECRUITINGThe 99th Central Hospital of the People's Liberation Army
Jiaozuo, Henan, China
RECRUITINGThe People's Hospital of Jiaozuo
Jiaozuo, Henan, China
RECRUITINGThe second people's Hospital of Jiyuan
Jiyuan, Henan, China
Coronary artery flow using thrombolysis in myocardial infarction (TIMI) flow grade after stent implantation
Grade 0, no myocardial blush or contrast density; grade 1, minimal myocardial blush or contrast density; grade 2, moderate myocardial blush or contrast density but less than that obtained during angiography of a contralateral or ipsilateral noninfarct-related coronary artery; grade 3, normal myocardial blush or contrast density comparable with that obtained during angiography of a contralateral or ipsilateral noninfarct-related coronary artery.
Time frame: 1 minute after stent implantation
Coronary artery flow using TIMI flow grade after balloon dilatation
Grade 0, no myocardial blush or contrast density; grade 1, minimal myocardial blush or contrast density; grade 2, moderate myocardial blush or contrast density but less than that obtained during angiography of a contralateral or ipsilateral noninfarct-related coronary artery; grade 3, normal myocardial blush or contrast density comparable with that obtained during angiography of a contralateral or ipsilateral noninfarct-related coronary artery.
Time frame: 1 minute after balloon dilatation
Coronary TIMI frame count after stent implantation
A continuous measurement assessing flow in the epicardial arteries.
Time frame: 1 minute after stent implantation
Coronary TIMI frame count after balloon dilatation
A continuous measurement assessing flow in the epicardial arteries.
Time frame: 1 minute after balloon dilatation
Slow flow / no-reflow phenomenon after stent implantation
Slow flow phenomenon means delayed progression or lack of contrast medium through the coronary tree.
Time frame: 1 minute after stent implantation
Slow flow / no-reflow phenomenon after balloon dilatation
Slow flow phenomenon means delayed progression or lack of contrast medium through the coronary tree.
Time frame: 1 minute after balloon dilatation
ECG ST-segment fall more than 50%
The extent of ST segment elevation was reduced by more than 50%
Time frame: in 2 hours post-PCI
Main adverse cardiovascular and cerebrovascular events (MACCE)
Death, Cardiac death, Rehospitalization (Heart failure) , Non-fatal myocardial infarction, Target vessel myocardial infarction, Target lesion revascularization, Target vessel revascularization, Ischemic-driven revascularization, Stent thrombosis, Bleeding, Cerebrovascular events, etc.
Time frame: at 1 day post-PCI, at follow up of 1, 3, 6,12 months post-PCI
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Huaihe Hospital of Henan University
Kaifeng, Henan, China
RECRUITINGKaifeng Central Hospital
Kaifeng, Henan, China
RECRUITINGThe First Affiliated Hospital of Henan University of Science and Technology
Luoyang, Henan, China
RECRUITINGLushan People's Hospital
Lushan, Henan, China
RECRUITINGNanyang City Center Hospital
Nanyang, Henan, China
RECRUITINGPingmei Shenma Medical Group General Hospital
Pingdingshan, Henan, China
RECRUITING...and 18 more locations