Sedation and Ease of Weaning From Mechanical Ventilation

Assiut University100 enrolled

Overview

Daily interruption of sedation is one of the modalities which is known to enhance early weaning and separation from mechanical ventilation . Daily sedation interruption is also known to help decreasing incidence of ventilator associated pneumonia. The new modality is no sedation.

there is an increase of incidence of chronic obstructive lung disease associated respiratory failure which necessitates invasive mechanical ventilation. It is well known that one of the bundles for enhanced recovery of such cases is the daily interruption of sedation . Recently studies have demonstrated the feasibility of just using sedation for initiation of mechanical ventilation, then utilization of no sedation technique as a more this offers less side effects .

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

100

Conditions

Respiratory Failure Midazolam Overdose Chronic Obstructive Pulmonary Disease Weaning Failure

Interventions

Daily interruption of midazolamDRUG

daily at 7 am midazolam infusion will be stopped spontaneous breath trial will be done

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Obstructive lung disease * Respiratory failure * Invasive mechanical ventilation Exclusion Criteria: * Neurological deficit * Cognitive dysfunction * Extensive malignancy * septic Shock

Locations (1)

Emad Zarief Kamel Said

Asyut, Egypt

Outcomes

Primary Outcomes

duration of mechanical ventilation

number of days of mechanical ventilation

Time frame: first 30 days

Data from ClinicalTrials.gov

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