MGD009/MGA012 Combination in Relapsed/Refractory Cancer

Inclusion Criteria: * Histologically-proven, unresectable locally advanced or metastatic solid tumors of any histology that test positive for B7-H3 expression on tumor cells or vasculature for whom no approved therapy with demonstrated clinical benefit is available. For all tumor types, the requirement for previous systemic therapy may be waived if a patient was intolerant of or refused standard first-line therapy * Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 * Life expectancy ≥ 12 weeks * Measurable disease, with the exception of prostate cancer * Tissue specimen available for B7-H3 and PD-L1 expression testing * Acceptable laboratory parameters * Patients who have previously received an immune checkpoint inhibitor (e.g., anti- PD-L1, anti-PD-1, anti-CTLA-4) prior to enrollment must have toxicities related to the checkpoint inhibitor resolved to ≤ Grade 1 or baseline (prior to the checkpoint inhibitor) to be eligible for enrollment. Patients who experienced previous hypothyroidism toxicity on a checkpoint inhibitor are eligible to enter study regardless of Grade resolution as long as the patient is well controlled on thyroid replacement hormones. Exclusion Criteria: * Patients with history of prior central nervous system (CNS) metastasis must have been treated, must be asymptomatic, and must not have any of the following at the time of enrollment: 1. No concurrent treatment for the CNS disease (e.g. surgery, radiation, corticosteroids \>10 mg prednisone/day or equivalent) 2. No progression of CNS metastases on MRI or CT for at least 14 days after last day of prior therapy for the CNS metastases 3. No concurrent leptomeningeal disease or cord compression * Patients with any history of known or suspected autoimmune disease with the specific exceptions of vitiligo, resolved childhood atopic dermatitis, psoriasis not requiring systemic treatment (within the past 2 years), and patients with a history of Grave's disease that are now euthyroid clinically and by laboratory testing * Treatment with any, investigational therapy within the 4 weeks prior to the initiation of study drug administration * Treatment with any systemic chemotherapy within 3 weeks * Treatment with radiation therapy within 2 weeks * History of allogeneic bone marrow, stem-cell, or solid organ transplant * Treatment with systemic corticosteroids (\> 10 mg per day prednisone or equivalent) or other immune suppressive drugs within 2 weeks * Clinically significant cardiovascular or pulmonary disease * Evidence of active viral, bacterial, or systemic fungal infection requiring parenteral treatment within 7 days prior to the initiation of study drug. Patients requiring any systemic antiviral, antifungal, or antibacterial therapy for active infection must have completed treatment no less than one week prior to the initiation of study drug. * Known history of positive testing for human immunodeficiency virus or history of acquired immune deficiency syndrome * Known history of hepatitis B or hepatitis C infection or known positive test for hepatitis B surface antigen, hepatitis B core antigen, or hepatitis C polymerase chain reaction