The Status of Autonomic Tone Before Tourniquet Deflation During Total Knee Replacement

Daegu Catholic University Medical Center40 enrolled

Overview

This study evaluates the influences of the status of sympathovagal balance before tourniquet deflation on a decrease in arterial blood pressure following the deflation during total knee replacement arthroplasty

Patients present with different hemodynamic profiles after intraoperative tourniquet deflation during total knee replacement arthroplasty. Sympathovagal balance can be measured before tourniquet deflation and might determine the hemodynamic response to tourniquet deflation.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Hypotension Blood Pressure, Low

Interventions

Tourniquet deflationPROCEDURE

Tourniquet deflation

Eligibility

Sex: ALLMin age: 50 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. American Society of Anesthesiologists physical status I - II 2. Body mass index \< 35 kg/m2 Exclusion Criteria: 1. Coagulation deficiencies 2. Known allergies to local anesthetics 3. Neurologic deficit on the side being operated on 4. Inflammation at the lumbar puncture site 5. Cardiac conduction disorders or arrhythmias 6. Congestive heart failure 7. Serum electrolyte abnormalities 8. Psychiatric disorders 9. Patient's refusal 10. Difficulty communicating with medical personnel 11. Severe hypovolemia 12. Increased intracranial pressure 13. Severe aortic stenosis 14. Severe mitral stenosis

Locations (1)

Daegu Catholic University Medical Center

Daegu, South Korea

Outcomes

Primary Outcomes

Sympathovagal balance

The ratio of low-to-high frequency power of heart rate variability calculated from the 5-minute long electrocardiogram waveform

Time frame: During 5 minutes before tourniquet deflation

Secondary Outcomes

Noninvasive hemodynamic parameters

Average cardiac index

Time frame: During 5 minutes before tourniquet deflation

Maximum percent change in mean arterial blood pressure

The discrepancy between minimum mean arterial blood pressure after tourniquet deflation and mean arterial blood pressure immediately before tourniquet deflation, which is divided by mean arterial pressure immediately before tourniquet deflation

Time frame: During 10 minutes after tourniquet deflation

Data from ClinicalTrials.gov

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