The effect of leucocyte- and platelet-rich fibrin (L-PRF) for enhancing the healing after dental extractions is still a matter of debate. The available literature suggests that L-PRF performs positive effect to improve alveolar preservation resulting in less bone resorption on extraction sockets. L-PRF is a second generation of platelet concentrate produced without biochemical blood manipulation. L-PRF is composed by three key parameters: first, the presence of platelets; second, the presence of leucocytes; third, the density and complex organization of the fibrin matrix architecture produced by a natural polymerization process. The theory is that this key parameters acts to produce a faster bone healing.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
48
The use of autologous platelet-rich fibrin after tooth extraction to promote bone healing and alveolar ridge preservation
Rio de Janeiro State University
Rio de Janeiro, Brazil
Width resorption 1mm
The ridge width differences between baseline and after three months of healing 1 mm below the crest.
Time frame: After 3 months
Width resorption 3mm
The ridge width differences between baseline and after three months of healing 3 mm below the crest.
Time frame: After 3 months
Width resorption 5mm
The ridge width differences between baseline and after three months of healing 5 mm below the crest.
Time frame: After 3 months
Histological Analysis - fibrous tissue
The percentage of soft (fibrous) tissue
Time frame: After 3 months
Histological Analysis - bone cells
Quantity of bone cells (osteoblast, osteoclast and osteocyte)
Time frame: After 3 months
Histological Analysis - capillary vessels
Quantity of capillary vessels
Time frame: After 3 months
Histological Analysis - new bone formation
The percentage of the newly formed bone
Time frame: After 3 months
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