Meal Enjoyment and Tolerance: Sex Differences

Hospital Universitari Vall d'Hebron Research Institute20 enrolled

Overview

Aim: to determine the effect of gender on the responses to meal ingestion. Participants (10 men and 10 women) will be instructed to eat a standard dinner the day before, to consume a standard breakfast at home after overnight fast, and to report to the laboratory, where the test meal will be administered 4 h after breakfast. Studies will be conducted in a quiet, isolated room with participants sitting on a chair. Participants will ingest a probe meal up to the level of maximal satiation. The probe meal will be served stepwise (150 Kcal every 5 min). Perception of homeostatic (hunger/satiation, fullness) and hedonic (digestive well-being, mood) sensations will be measured at 5 min intervals 10 min before, during and 20 min after ingestion at 10 min intervals.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

SINGLE

Enrollment

Conditions

Healthy

Interventions

The probe meal will be served in 150 Kcal portions (10 g foie, 10 g cheese, 5 g chips, 2 g peanuts, 3 g toast, and 27 mL soft drink) up to the level of maximal satiation.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * non-obese Exclusion Criteria: * history of gastrointestinal symptoms * prior obesity * use of medications * history of anosmia and ageusia * current dieting * alcohol abuse * psychological disorders * eating disorders

Locations (1)

University Hospital Vall d'Hebron

Barcelona, Spain

Outcomes

Primary Outcomes

Meal tolerance

Amount of meal (Kcal) consumed up to the level of maximal satiation (score 5 on a - 5 to + 5 score hunger/satiation scale).

Time frame: 100 min

Secondary Outcomes

Change in digestive well-being induced by the probe meal

Change in well-being measured by 10 score scales during and after the probe meal.

Time frame: 1 day

Change in fullness sensation induced by the probe meal

Change in fullness sensation measured by 10 score scales during and after the probe meal.

Time frame: 1 day

Change in mood induced by the probe meal

Change in mood measured by 10 score scales during and after the probe meal.

Time frame: 1 day

Change in abdominal discomfort induced by the probe meal

Change in abdominal discomfort measured by 10 score scales during and after the probe meal.

Time frame: 1 day

Change in hunger/satiety induced by the probe meal

Change in hunger/satiety measured by 10 score scales during and after the probe meal.

Time frame: 1 day

Data from ClinicalTrials.gov

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