Observational, multi-centre, prospective study to investigate the feasibility of centralized TDM of moxifloxacin and levofloxacin in MDR-TB patients by determining turn-around time between sampling and receiving dosing advice. In addition, the effect of TDM will be evaluated by comparing treatment results of prospective patients receiving TDM with historical controls without TDM.
Study Type
OBSERVATIONAL
Enrollment
360
Plasma samples will be drawn at peripheral centres en shipped to a central laboratory for analysis. Results and dosing advice will be returned by email to local physician.
The Prince Charles and Caboolture Hospitals
Brisbane, Australia
NOT_YET_RECRUITINGRepublican Scientific and Practical Centre of Pulmonology and Tuberculosis
Minsk, Belarus
Feasibility of centralized TDM
Turn-around time between plasma sampling and receiving dosing advice
Time frame: 1 week
Impact of centralized TDM
Comparison of % patients with converted sputum smear and culture between prospective patients with TDM and matched historical controls without TDM (1:2)
Time frame: 2 months
Simone van den Elsen, BSc
CONTACT
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