Effects of Concord Grape Juice Alone on Glycemia, Appetite and Cognitive Function in Healthy Adults

Purdue University40 enrolled

Overview

Assess the impact of 100% grape juice on postprandial glycemic response and subsequent appetite, food intake and cognitive function.

Investigators earlier clinical work and published literature suggest that the phenolic content and strong flavor intensity of 100% Concord grape juice hold potential beneficial effects on appetite and glycemia. Investigators aim to better understand the use of 100% grape juice modifies appetite and glycemia acutely and over the day using a 24 hour glucose monitor.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Glycemic Response Appetitive Behavior

Interventions

Concord Grape JuiceOTHER

Concord Grape Juice

Low flavoniod low essence beverageOTHER

Low flavoniod low essence beverage

Low flavonoid beverageOTHER

Low flavonoid beverage

Eligibility

Sex: ALLMin age: 25 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * BMI between 25.0-34.9 kg/m2 * Willingness to eat all test foods * Low consumer of tea and coffee, willingness to refrain from both during the 48 hours prior to test days and on the test day. * Fasting blood glucose below 6.1mmol/l via capillary finger-stick blood sample using a SureStep glucometer (Lifescan, Milpitas, CA) Exclusion Criteria: * Taking medications known to affect glycemia, lipid metabolism or appetite * Body weight fluctuation of \>5kg in the past 3 months * Taking vitamin or other supplements * Smokers * Acute or Chronic disease

Locations (1)

Purdue University

West Lafayette, Indiana, United States

Outcomes

Primary Outcomes

Change in blood glucose over 24 hours

samples taken every 5 minutes for 24 hours by a continuous glucose monitor

Time frame: 24 hours

Secondary Outcomes

Appetite

Questionnaire on hunger, fullness, desire to eat, prospective consumption, thirst taken hourly on same day as grape juice intervention

Time frame: 24 hours

Data from ClinicalTrials.gov

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