The purpose of this study is to determine if cognitive function improves in patients converted from tacrolimus immediate release (TAC IR) to Envarsus XR® (tacrolimus extended release) using an objective measure of cognition.
To assess cognitive function while on TAC IR and then three months after conversion to TAC XR using a traditional cognitive assessment, Montreal Cognitive Assessment (MoCA), and a broader cognitive assessment. This assessment will be used to determine if there is an objective improvement in cognitive function after conversion from TAC IR to TAC XR in kidney transplant recipients.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
28
After conversion of tacrolimus immediate release to tacrolimus extended release.
Yale New Haven Transplantation Center
New Haven, Connecticut, United States
cognitive assessment at baseline
cognitive assessment at baseline using MoCA test 7.1
Time frame: baseline
cognitive improvement from baseline
cognitive evaluation from baseline average for adults using NIH Toolbox Cognitive Domain
Time frame: 3 months after enrollment
MoCA cognitive assessment
cognitive assessment using MoCA 7.2
Time frame: 3 months after enrollment
NIH Toolbox cognitive test
NIH Toolbox Flanker Inhibitory Control and Attention Test
Time frame: baseline
NIH Toolbox cognitive test
NIH Toolbox Flanker Inhibitory Control and Attention Test
Time frame: 3 months
NIH Toolbox cognitive test
NIH Toolbox Dimensional Change Card Sort Test
Time frame: baseline
NIH Toolbox cognitive test
NIH Toolbox Dimensional Change Card Sort Test
Time frame: 3 months
NIH Toolbox cognitive test
NIH Toolbox Picture Sequence Memory Test Version A
Time frame: baseline
NIH Toolbox cognitive test
NIH Toolbox Picture Sequence Memory Test Version B
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Time frame: 3 months
NIH Toolbox cognitive test
NIH Toolbox Pattern Comparison Processing Speed Test
Time frame: baseline
NIH Toolbox cognitive test
NIH Toolbox Pattern Comparison Processing Speed Test
Time frame: 3 months
NIH Toolbox cognitive test
NIH Toolbox List Sorting Working Memory Test
Time frame: baseline
NIH Toolbox cognitive test
NIH Toolbox List Sorting Working Memory Test
Time frame: 3 months
NIH Toolbox cognitive test
NIH Toolbox Reading Recognition Test
Time frame: baseline
NIH Toolbox cognitive test
NIH Toolbox Reading Recognition Test
Time frame: 3 months