Outcomes of Intrathecal Analgesia in Colorectal Surgery

Mayo Clinic601 enrolled

Overview

Multimodal analgesia, sometimes including intrathecal analgesia (IA), is essential in any enhanced recovery pathway (ERP). This study aimed to evaluate the safety, feasibility, and optimal IA regimen in colorectal surgical patients.

Study Type

OBSERVATIONAL

Enrollment

601

Conditions

Surgery

Interventions

Hydromorphone HydrochlorideDRUG

All intrathecal injections were performed preoperatively using a 22g or 25 g Whitacre or 24g Sprotte spinal needle. The IA regimen, medication(s) and dose(s), was at the discretion of the attending anesthesiologist, and consisted of one of the following regimens: (1) hydromorphone + local anesthetic (IA-L), or (2) hydromorphone only (IA-O). In patients receiving IA, no other interventional locoregional analgesic techniques (such as rectus sheath blocks or transversus abdominis plane blocks) were utilized.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * All adult colorectal patients from October 2012 through December 2013 in which patients received single-injection IA as part of a multimodal analgesic strategy for ERP. * Undergoing an elective colorectal operation (minimally invasive or open) Exclusion Criteria: * Patients aged \< 18 years * American Society of Anesthesiologists (ASA) 5 and 6 classification * pregnancy * failure to provide research authorization. * emergent operations

Locations (2)

Mayo Clinic

Jacksonville, Florida, United States

Mayo Clinic

Rochester, Minnesota, United States

Outcomes

Primary Outcomes

Time to return of bowel function

Time to return of bowel function is defined by the presence of flatus and a bowel movement

Time frame: post resection, approximately up to 48 hours

Data from ClinicalTrials.gov

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