In this study, the investigator will try to highlight the presence of carbonyl compounds in the hair follicles of women with telogen effluvium (ET) linked to stress of various origins (fatigue, infectious diseases, emotional stress ...).
At the cutaneous level, oxidative stress induces the formation of carbonyl compounds which, by binding to proteins, produce nonfunctional adducts inducing cutaneous aging. Is this mechanism, called "Carbonyl stress", also present in the scalp and can it be one of the mechanisms involved in the occurrence of reactive hair loss ? To demonstrate this, samples of hair follicles are made. The proteins are extracted from the samples and then assayed. The oxidized (carbonyl) proteins are labeled with specific fluorescent probes.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
40
The follicles will be collected by lock of 10 hair on the scalp (centro-parietal part), to obtain 40 follicles with epithelial sheath
Centre hospitalier Lyon Sud
Lyon, France
Centre de Pharmacologie Clinique Appliquée à la Dermatologie
Nice, France
Centre de santé SABOURAUD
Paris, France
INTERTEK France
Paris, France
Biological evaluation
Evaluation of the quantity of carbonyl compounds measured in the hair follicles taken from the two groups.
Time frame: Visit 1- Day 1
Safety evaluation
Adverse events evaluation
Time frame: Visit 1- Day 1
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Centre de Recherche sur la Peau
Toulouse, France
Laboratoire Dermscan
Villeurbanne, France