Multiple Ascending Doses of Globalagliatin Hydrochloride in Type 2 Diabetes Mellitus

Inclusion Criteria: 1. Sex：Male and Female； 2. Age：≥18，≤70； 3. Have T2DM prior to entering the trial based on the disease diagnostic criteria (WHO, 1999), and currently being treated with diet and exercise only or in combined with a stable dose of metformin for at least 8 weeks. 4. 18 kg/m2≤BMI≤35 kg/m2 at screening. 5. 7% ≤ HbA1c ≤11% at screening. 6. 7 mmol/L≤FPG≤13.3mmol/L at baseline. 7. The venous access is normal, and blood samples can be collected according to the protocol. 8. Have given written informed consent to participate in this study. 9. Are well motivated, capable, and willing to communicate with the investigator and complete all the requirements according to the protocol. Exclusion Criteria: 1. Personnel and their direct relatives of the clinical research unit and its related facilities. Direct relatives mean all biologically and by law related relatives, including spouse, parent, child and sibling, 2. Have been diagnosed with type 1 diabetes, or gestational diabetes mellitus, or a specific type of diabetes mellitus. 3. Clinically significant coronary events or symptoms within 6 months prior to study entry. 4. Clinically significant peripheral vascular disease. 5. Clinical evidence of active diabetic proliferative retinopathy. 6. Known clinically significant autonomic neuropathy as evidenced by urinary retention, orthostatic hypotension, diabetic diarrhea or gastroparesis. 7. With a history of diabetes or diabetic ketoacidosis, lactic acidosis, hyperosmolar nonketotic coma history. 8. Have severe hypoglycemia occurred before the screening with unknown causes (need other people to help restore) or the frequency of hypoglycemia, such as 3 or more hypoglycemic events(blood glucose ≤3.9mmol/L) within 1 months before screening or hypoglycemia related symptoms. 9. Continuous use of insulin for more than 1 month in last year. 10. Have any disorder or unstable situation of the endocrine system, immune system or other diseases impaired blood sugar(such as Hyperthyroidism, acromegaly, Cushing syndrome) that are required treatment 11. Have significant history of past or current cardiovascular, respiratory, hepatic, renal, gastrointestinal, endocrine (other than diabetes), hematological, or neurological disorders capable of significantly altering the absorption, metabolism or elimination of drugs or of constituting a risk when taking the study drug formulations or interfering with the interpretation of data. 12. Have any types of malignancies (whether cured or not). 13. History of haemoglobin disease（such as sickle cell anemia or thalassemia, iron deficiency anemia）. 14. Have known allergies to Globalagliatin or related compounds, or have allergic history, or have taken glucokinase activator in last year. 15. Are currently enrolled in, or discontinued within the last 3 months from, a clinical trial involving an investigational drug or device or use of a drug or device other than the study drug used in this study, or are concurrently enrolled in any other type of medical research judged not to be scientifically or medically compatible with this study. 16. Have a history of drug or alcohol abuse. 17. Have history of blood donation in last 6 months. 18. Patients who have an average weekly alcohol intake that exceeds 21 units per week (males) and 14 units per week (females) (1 unit = 360 mL of beer; 150 mL of wine; 45 mL of distilled spirits) or patients unwilling to stop alcohol consumption 24 hours prior to admission until the completion of each in-patient study period. 19. Patients who smoke \>10 cigarettes or other tobacco products per day before study entry. Patients are unlikely / unable to stop nicotine intake during the study period. 20. Fasting serum C peptide\< 1.0 ng/ml（333pmol/L）at screening. 21. Patients are treated with stable dose of anti-hypertension drug at least for 4 weeks with inadequate blood pressure control (sitting systolic blood pressure≥160mmHg or diastolic blood pressure≥100mmHg)at screening. 22. QTcB≥450msec at screening. 23. Fasting serum triglycerides\>500mg/dL（5.70mmol/L）at screening. 24. ALT (alanine aminotransferase) \>1.5 ULN, AST (aspartate transaminase) \>1.5×ULN or TBIL (total bilirubin) \> 1.5×ULN (UIN :times the upper limit of the reference range)at screening; or have active liver diseases at screening. 25. Serum creatinine\>133μmol /L at screening. 26. Use of any known inducers or inhibitors of CYP3A (Cytochrome P450 3A) within 14 days prior to the first dosing with study drug or intended use during the study. Examples of inducers include, but are not limited to, phenytoin, barbiturates, carbamazepine, St. John's Wort, rifampin. Examples of inhibitors include, but are not limited to, fluvoxamine, sertraline, norfloxacin, macrolide antibiotics (erythromycin, clarithromycin), antifungals, human immunodeficiency virus (HIV) protease inhibitors, cyclosporine, diltiazem, pomelo, grapefruit juice. 27. Have been previously enrolled in or withdrawn from this clinical trial. 28. Evidence of positive HBsAg, or IgM (immunoglobulin M ) anti-HBc (hepatitis B core antigen), or anti-HCV (hepatitis C virus ), or anti-HIV, or anti-TPat (treponema pallidum antibody) screening. 29. fertility qualified subjects（Male and Female）are unlikely to use reliable contraception during study period and at least 1 month after last dosing or women in child-bearing age have positive for blood pregnancy tests within 24 hours before enrollment, or pregnant or lactating women. 30. Patients, in opinion of investigator or sponsor, are not suitable for this clinical trial.