Dietary Anthocyanins Improve Lipid Metabolism in a Dose - Dependent Manner

Sun Yat-sen University169 enrolled

Overview

In order to study the effect of anthocyanins on the improvement of glucose and lipid metabolism, randomized intervention trials were conducted to compare the effects of anthocyanins on the improvement of glucose and lipid metabolism in different dose groups.To explore the best dose of anthocyanins for the prevention and treatment of anthocyanin metabolic diseases provide an important scientific basis.

In order to study the effect of anthocyanins on the improvement of glucose and lipid metabolism, randomized controlled trials were conducted to enrolled 300 patients with dyslipidemia. The subjects were divided into 0 mg / d, 40 mg / d, 80 mg / d, 320 mg/ d five dose groups, intervention for 12 weeks, comparing different doses of anthocyanins on glucose and lipid metabolism.To explore the best dose of anthocyanins for the prevention and treatment of anthocyanin metabolic diseases provide an important scientific basis.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

169

Conditions

Dyslipidemias

Interventions

Medox® Anthocyanin capsulesDRUG

Subjects were orally administered Medox® capsules daily for 12 weeks.

Eligibility

Sex: ALLMin age: 35 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Dyslipidemia * Subjects with dyslipidemia who also have prediabetes * The age between 35 and 70 years old Exclusion Criteria: * intake of any medicine that affect lipid and glucose metabolism currently or in the preceding 6 months * dietary supplementation with phytochemicals including anthocyanins in the preceding 2 months * history of acute or chronic infectious disease, autoimmune disease, cancer, traumatic injury, or surgery in the preceding 1 month * history of severe chronic disease including AS and CVD, liver or renal dysfunction, and lactation or pregnancy * Pregnant woman and Breast Feeding Women

Locations (1)

Department of Nutrition and Food Hygiene,School of Public Health, Sun Yat-sen University

Guangzhou, Guangdong, China

Outcomes

Primary Outcomes

Anthocyanins dose-dependently improved blood lipids in patients with dyslipidemia.

After 12 weeks intervention of anthocyanins, serum lipid profiles were measured at baseline, at 6 weeks, and at the end of 12 weeks.

Time frame: 12 weeks

Secondary Outcomes

Anthocyanin supplementation improves cholesterol efflux capacity in a dose-response manner in subjects with dyslipidemia

After 12 weeks intervention of anthocyanins,cholesterol efflux capacity (CEC) were measured at baseline, at 6 weeks, and at the end of 12 weeks.

Time frame: 12 weeks

Anthocyanins supplementation improve anti-oxidative and anti-inflammation capacity in a dose-response manner in subjects with dyslipidemia.

After 12 weeks intervention of anthocyanins,Urine 8-iso-prostaglandinF2α (8-iso-PGF2α), 8-hydroxy-2'-deoxyguanosine (8-OHdG) and serum malondialdehyde (MDA), superoxide dismutase (SOD), UA (urine acid), interleukin-6 (IL-6), interleukin-10(IL-10), tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP) were measured at baseline, at 6 weeks and at the end of 12 weeks.

Time frame: 12 weeks

Anthocyanins supplementation attenuate platelet hyperreactivity in a dose-response manner in subjects with dyslipidemia.

After 12 weeks intervention of anthocyanins, platelet aggregation, the expression of P-selectin (CD62p) activated GPⅡbⅢa (PAC-1), platelet reactive oxygen species (ROS) and platelet mitochondrial membrane potential (TMRM) were measured at baseline, at 6 weeks and at the end of 12 weeks.

Time frame: 12 weeks

Data from ClinicalTrials.gov

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