The medium cut-off dialysis (MCO) membrane has been developed to improve middle molecule removal compared to standard high-flux dialysis filters. The aim of this study is to compare levels of middle molecules after 12 weeks of MCO hemodialysis, compared to 12 weeks of hemodiafiltration using standard high-flux filter.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Measurements will be done after 0,4,8 and 12 weeks of hemodialysis with Medium Cut-Off filter.
Measurements will be done after 0,4,8 and 12 weeks of hemodiafiltration with standard high-flux filter
Comparison of predialysis mean of middle molecules after 12 weeks (Beta-2-microglobulin, Cystatin C, Myoglobin, Beta-Trace Protein, Troponin T, Prealbumin).
Time frame: 12 weeks
Comparison of postdialysis mean of middle molecules after 12 weeks (Beta-2-microglobulin, Cystatin C, Myoglobin, Beta-Trace Protein, Troponin T, Prealbumin).
Time frame: 12 weeks
Comparison of predialysis mean of small molecules (CRP, Urea, Phosphate and Creatinine) after 12 weeks.
Time frame: 12 weeks
Comparison of postdialysis mean of of small molecules (CRP, Urea, Phosphate and Creatinine) after 12 weeks.
Time frame: 12 weeks
Comparison of predialysis mean of large molecules after 12 weeks (Albumin, Transferrin, IgG).
Time frame: 12 weeks
Comparison of postdialysis mean of large molecules after 12 weeks (Albumin, Transferrin, IgG).
Time frame: 12 weeks
Comparison of pre- and postdialysis mean of all molecules at 0, 4 and 8 weeks.
Time frame: 8 weeks
Comparison of number of adverse effects during the study period.
Time frame: 12 weeks
Comparison of mean nPCR after 12 weeks.
Time frame: 12 weeks
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