TMAO and Atherosclerosis in HIV

Albert Einstein College of Medicine737 enrolled

Overview

In the present study, the investigators sought to prospectively examine the associations of plasma levels of TMAO (trimethylamine oxide), choline, betaine, dimethylglycine, and sarcosine with risk of incident carotid artery plaque, assessed by repeated B-mode carotid artery ultrasound imaging over a 7-year period, in women and men with and without HIV infection from the WIHS (Women Interagency HIV Study) and MACS (Multicenter Aids Cohort Study).

Study Type

OBSERVATIONAL

Enrollment

737

Conditions

Carotid Artery Plaque

Interventions

No interventionOTHER

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * participants who underwent carotid artery imaging for plaque assessment at a baseline visit (2004-2006) and at a follow-up visit (2011-2013). Exclusion Criteria: * a history of coronary heart disease, individuals with prevalent diabetes or prevalent carotid artery plaques at baseline

Outcomes

Primary Outcomes

incident carotid artery plaque

assessed by repeated B-mode carotid artery ultrasound imaging

Time frame: 2011-2013

Data from ClinicalTrials.gov

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