SMAS: a Prospective Study in a Single Institution

Azienda Ospedaliera di Padova39 enrolled

Overview

Superior Mesenteric Artery Syndrome (SMAS) is a rare cause of duodenal obstruction, that should be suspected in cases of chronic, refractory upper digestive symptoms. Between 2008 and 2016, 39 consecutive patients with chronic gastrointestinal symptoms and a diagnosis of SMAS were prospectively included in the study, in order to describe their demographic, clinical and outcome features. All patients underwent duodenojejunostomy.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Superior Mesenteric Artery Syndrome

Interventions

DuodenojejunostomyPROCEDURE

Duodenojejunostomy with or without duodenal resection

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria (at least 2 of the following): * severe and frequent upper digestive symptoms (occurring at least once a week), associated to poor quality of life and refractory response to medical treatment; * a condition of underweight (BMI \<18.5 kg/m2) associated with difficulty eating; * severe complications of SMAS (e.g. gastric perforation, acute pancreatitis, aspiration pneumonia); * suggestive findings of SMAS at barium swallow; * diagnostic aortomesenteric angle and distance at CT/MR angiography. Exclusion Criteria: * inability to provide the informed consent; * malignancies; * bowel motility disorders; * severe psychiatric illness; * pregnancy; * impossibility to perform the required diagnostic workup.

Locations (1)

General Surgery Unit

Padua, PD, Italy

Outcomes

Primary Outcomes

Symptom score

Severity (0-6) + frequency (0-5) x 5 symptoms (abd pain, nausea, vomiting, reflux, bloating)

Time frame: 47 months (IQR 34-72)

BMI

Body mass index

Time frame: 47 months (IQR 34-72)

Need for medical treatment

PPIs, prokinetic drugs

Time frame: 47 months (IQR 34-72)

Data from ClinicalTrials.gov

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