Study Evaluating the Efficacy and the Tolerance of Pelvic-prostatic Hypo-fractionated Radiotherapy Followed by Boost in Patients With Prostate Adenocarcinoma Adverse Intermediate Risk or High Localized Risk

Inclusion Criteria: 1. Adenocarcinoma of the prostate 2. Patient with one of the following cases: * Gleason 7 - 10 + T1c - T2b + PSA \< 50 ng/mL or * Gleason 6 + T2c - T4 ou envahissement ≥ 50% sur les biopsies + PSA \< 50 ng/mL or * Gleason 6 + T1c - T2b + PSA \> 20 ng/mL 3. Risk of lymph node involvement\> 15% 4. Patient N0, or Nx 5. Prostate volume estimated on MRI or ultrasound less than 60 cc. 6. Absence of pelvic lymphadenopathy ≥ 15 mm on CT or MRI extension assessment 7. Lack of bone and / or visceral metastasis on CT scan and bone scintigraphy 8. Hormonal treatment started maximum 90 days before the beginning of the irradiation, 9. IPSS score \<12 without alpha blocker treatment 10. Absence of prior pelvic radiotherapy, 11. Lack of surgical treatment for prostate cancer except transurethral resection performed within 6 months before radiotherapy, 12. Age ≥ 18 years and ≤ 85 years, 13. WHO performance index ≤ 1, 14. Estimated life expectancy\> 5 years, 15. Indication of treatment with radiotherapy and validated hormone therapy in a multidisciplinary consultation meeting 16. Affiliation to a social security scheme, 17. Signed informed consent. Exclusion Criteria: 1. Prostate cancer of histology other than adenocarcinoma, 2. Patient diagnosed with N1 during imaging or pN1, 3. serum PSA level\> 100 ng / ml, 4. IPSS score ≥ 12 or alpha blocker treatment, 5. Prostate volume estimated on MRI or ultrasound\> 60 cc 6. History of cancer in the 5 years prior to entry into the trial, 7. History of trans-urethral resection of prostate less than 6 months old, 8. History of rectal surgery, 9. History of pelvic irradiation, 10. Patient with severe hypertension not controlled by appropriate treatment, 11. Contraindication to pelvic irradiation, 12. Patient not eligible for brachytherapy * Prostate volume\> 60cc * Urine flow measurement with max flow \<12 mL / s * Or curative anticoagulant treatment * Or contraindication to general anesthesia 13. Patient treated with antineoplastic or drug may include methotrexate, 14. Hormone therapy started\> 90 days before the first irradiation, 15. Patient on immunosuppressant therapy 16. Contraindication to agonists or antagonists of LHRH, 17. Bilateral hip prosthesis, 18. Patient already included in another therapeutic trial with an experimental molecule, 19. Patient unable to cooperate during treatment, 20. Persons deprived of their liberty or guardianship, 21. Inability to undergo medical follow-up of the test.