Effects of Anesthesia With Propofol Versus Desflurane in Obese Patients

Centre Hospitalier Universitaire Saint Pierre40 enrolled

Overview

Evaluate the effects of propofol compared with desflurane on oxidative stress and inflammation markers in obese patients undergoing scheduled bariatric surgery.

Obese patients have a high level of oxidative stress and inflammation activity. Desflurane is an anesthetic gas often used for obese patients. Propofol, another anesthetic agent, has shown an antioxidant property. The aim of the study is to compare the effects of propofol with desflurane on oxidative stress and inflammation markers in obese patients.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Anesthesia Obesity

Interventions

Desflurane Inhalant ProductDRUG

General anesthesia will be induced with sufentanyl (0.2µg/kg) and thiopental (5mg/kg) and maintained by desflurane

PropofolDRUG

General anesthesia will be induced with propofol (2mg/kg) and sufentanyl (0.2µg/kg) and maintained by propofol in a target-controlled infusion mode

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Body Mass Index (BMI) \>35 * scheduled gastric by pass surgery * American Society of Anesthesiologists (ASA) \<III Exclusion Criteria: * Allergic to anesthesia agent * patient refusal

Outcomes

Primary Outcomes

Malondialdehyde (MDA) level in blood sample

Plasma MDA level is measured as an oxidative stress marker before the surgery, at 1 hour, 2 hours, 24 hours post-surgical incision.

Time frame: up to 24 hours post bariatric surgery

Secondary Outcomes

C-Reactive Protein (CRP) in blood sample

Plasma CRP level is measured as an inflammation marker before the surgery, at 1 hour, 2 hours, 24 hours post-surgical incision.

Time frame: up to 24 hours post bariatric surgery

Monocyte level in blood sample

Monocyte level is measured as an inflammation marker before the surgery, at 1 hour, 2 hours, 24 hours post-surgical incision.

Time frame: up to 24 hours post bariatric surgery

Pain assessed by Visual Analog Scale (VAS)

Pain level is determined at 2 hours, 24 hours and 48 hours post-surgical incision. Visual analog pain score (scale = 0 no pain; 10= worst pain imaginable)

Time frame: up to 48 hours after surgery

Side-effects (nausea, vomiting, somnolence, respiratory depression)

Evaluation at 2 hours, 24 hours and 48 hours post-surgical incision

Time frame: up to 48 hours after surgery

Data from ClinicalTrials.gov

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