Hyperpolarized Xenon MRI for Assessment of Pulmonary Function in Lung Transplant

Inclusion Criteria: 1. Male or female subjects ≥18 years of age. 2. Subject is being evaluated for possible lung transplant surgery (either single or bilateral). 3. Subject is able to undergo MRI imaging and able to fit in the MRI coil. 4. Subject is willing and able to comply with all study procedures. 5. Subject must understand and voluntarily sign an informed consent form (ICF) prior to any study specific assessments or procedures. Exclusion Criteria: 1. Baseline blood oxygen saturation (SpO2) \<90% at rest. For subjects requiring routine supplemental oxygen, SpO2 measurements should be taken with the patient's normal oxygen supplementation. 2. Subjects that have undergone a prior pneumonectomy surgery to either lung. 3. Female subjects of childbearing potential with a positive serum pregnancy test at screening, or who are not taking (or not willing to take) acceptable birth control measures through the Follow-up Period. Adequate birth control methods include with a monogamous partner who was sterilized more than 6 months prior to screening, or measures with a Pearl index of \<1 used consistently and correctly (including intrauterine devices, or implantable, injectable, oral, or transdermal contraceptives). Women are not considered to be of childbearing potential if they meet at least 1 of the following 2 criteria as documented by the Investigator: * They have had a hysterectomy, bilateral salpingectomy, or bilateral oophorectomy at a minimum of 1 menstrual cycle prior to signing the ICF; or * They are post-menopausal: for women ≥55 years of age, defined as ≥1 year since their last menstrual period, or for women \<55 years of age, defined as ≥1 year since their last menstrual period and have a follicle-stimulating hormone (FSH) level in the laboratory's normal range for post-menopausal phase. 4. Women who are lactating and insist on breast feeding. 5. Have received any other investigational therapy within 4 weeks prior to Screening. 6. Requires anesthesia or heavy sedation to undergo MRI testing. Mild sedation could be acceptable (i.e. a low dose oral acting anxiolytic medication such as alprazolam) as long as, in the opinion of the investigator, the subject meets Inclusion Criteria #4 and #5.