The gastric barrier plays a major role in the maintanance of the distal intestinal microbiome composition. It has been shown before that the use of gastric acid suppression medication, such as proton pump inhibitors, are associated with distinctive alterations of the intestinal microbiome. Foremost, the invasion of predominantly oral bacteria, like Veillonella and Streptococcus species, were a resurring finding in previous reports. Gastric cancer treatment includes the total or subtotal resection of the stomach which can influence the gastric acid production. However, the influence by alterations in gastric milieu after this treatment on the composition of the intestinal microbiome is not well studied. Therefore, the intestinal microbiome of patients after total or subtotal gastrectomy and its influence on intestinal inflammation and gut permeability will be studied.
Study Type
OBSERVATIONAL
Enrollment
34
National Cancer Institute
Vilnius, Lithuania
Intestinal microbiome composition
Significant differences in the beta-diversity of the intestinal microbiome between Test group and Control groups
Time frame: 5 years after surgery
Intestinal microbiome composition (II)
Significant differences in the alpha-diversity of the intestinal microbiome between Test group and Control groups
Time frame: 5 years after surgery
Fecal calprotectin
Significant differences in intestinal inflammation measured by fecal calprotectin between Test group and Control groups
Time frame: 5 years after surgery
Fecal zonulin
Significant differences in intestinal permeability measured by fecal zonulin between Test group and Control groups
Time frame: 5 years after surgery
Serum LPS
Significant differences in serum LPS between Test group and Control groups
Time frame: 5 years after surgery
Serum sCD14
Significant differences in serum sCD14 between Test group and Control groups
Time frame: 5 years after surgery
Serum LBP
Significant differences in serum LBP between Test group and Control groups
Time frame: 5 years after surgery
Serum sCD163
Significant differences in serum sCD163 between Test group and Control groups
Time frame: 5 years after surgery
Serum sMR
Significant differences in serum sMR between Test group and Control groups
Time frame: 5 years after surgery
Serum CRP
Significant differences in serum CRP between Test group and Control groups
Time frame: 5 years after surgery
Serum DAO
Significant differences in serum DAO between Test group and Control groups
Time frame: 5 years after surgery
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