This study is designed to verify the clinical efficacy and safety of different statins in dyslipidemia patients, and explore the effects on glycometabolic in patients with impaired glucose regulation.
Study Objective: 1. The main Objective: To explore the effects of different statins lipid-lowering treatment on glucose metabolism in patients with impaired glucose regulation in a large sample of Chinese population; 2. The secondary Objective: To obtain real-world evidence of the clinical efficacy and safety of statins lipid-lowering therapy in Chinese patients. Study Design: The study was an open-label, multi-center network register-based follow-up study. The total sample size: 10000 participants.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
10,000
Capsule/Tablet, oral, follow the doctor's advice Participants will receive pitavastatin treatment for 3 or 12 weeks.
Capsule/Tablet, oral, follow the doctor's advice Participants will receive atorvastatin treatment for 3 or 12 weeks.
Capsule/Tablet, oral, follow the doctor's advice Participants will receive rosuvastatin treatment for 3 or 12 weeks.
Heart Center of Peking University People's Hospital
Beijing, Beijing Municipality, China
School of Public Health, Fudan University
Shanghai, Shanghai Municipality, China
LDL-C target achieving rate
To measure the levels of LDL-C in mmol/L and calculate the LDL-C target achieving rate.
Time frame: 3 months
Blood lipid parameters
The levels of total cholesterol (TC) in mmol/L
Time frame: 3 months
Blood lipid parameters
The levels of triglyceride (TG) in mmol/L
Time frame: 3 months
Blood lipid parameters
The levels of low density lipoprotein cholesterol (LDL-C) in mmol/L
Time frame: 3 months
Blood glucose levels
To measure the level of glycosylated hemoglobin (HbA1) in percent (%)
Time frame: 1 year
Fasting blood glucose
The levels of fasting blood glucose (FBG) in mmol/L
Time frame: 1 year
Blood lipid parameters
The levels of total cholesterol (TC) in mmol/L
Time frame: 1 year
Blood lipid parameters
The levels of triglyceride (TG) in mmol/L
Time frame: 1 year
Blood lipid parameters
The levels of low density lipoprotein cholesterol (LDL-C) in mmol/L
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Time frame: 1 year
Blood lipid parameters
The levels of High density lipoprotein cholesterol (HDL-C) in mmol/L
Time frame: 1 year
Incidence of Treatment-Emergent Adverse Events [Safety and Tolerability]
To evaluate the safety and tolerability of the three statins, the incidence of treatment-emergent adverse events should be recorded though the study.
Time frame: Through study completion, an average of 1 year