PBMT on Muscular Performance and Recovery in Different Time-points

N/ACompletedNCT03420391

University of Nove de Julho60 enrolled

Overview

Recent studies with photobiomodulation therapy (PBMT) have shown positive results delaying skeletal muscle fatigue and improving the status of biochemical markers related to skeletal muscle damage when these therapies were applied before exercise. The aim of this project is to verify the effects of PBMT in improvement of skeletal muscle performance and skeletal muscle recovery in healthy male subjects. This project aim also to validate the concept that simultaneous use of three wavelengths and light sources lead to optimized action independently of time-window between irradiation and the exercise.

This is a randomized, triple-blinded, placebo-controlled trial. Sixty healthy untrained male subjects will be randomly allocated to six experimental groups: Placebo, Control, PBMT 5 mins, PBMT 3h, PBMT 6h and PBMT 24 hours. PBMT will be applied precisely two minutes after baseline MVC test. Then, after five minutes, 3, 6 hours or 1 day (24 hours) of PBMT the eccentric exercise protocol will be performed. We will analyze maximum voluntary contraction (MVC), creatine kinase (CK) activity and delayed onset muscle soreness (DOMS). Assessments will be performed at baseline, immediately after (1 minute), 1 hour, 24 and 48 hours after the eccentric exercise protocol.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Enrollment

Conditions

Phototherapy

Interventions

Photobiomodulation Therapy (PBMT)DEVICE

Phototherapy device - Multi Radiance Medical® (Solon, OH, EUA)

Eligibility

Sex: MALEMin age: 18 YearsMax age: 35 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy * not athletes or who engage in physical activity at most once a week * Individuals should not present a history of musculoskeletal injury in the hip and knee regions in the two months prior to the studies * they should not be using pharmacological agents and / or nutritional supplements * They must attend 100% of the data collections. Exclusion Criteria: * Individuals who do not meet the criteria mentioned above or who present musculoskeletal damage during collection were excluded from the study.

Locations (1)

Universidade Nove de Julho

São Paulo, Brazil

Outcomes

Primary Outcomes

Torque peak / maximum voluntary contraction - MVC

Assessment was performed in the isokinetic dynamometer (System 4, Biodex®, USA)

Time frame: 1 minute, 1 hour, 24 and 48 hours after the end of exercise protocol.

Secondary Outcomes

Delayed onset muscle soreness (DOMS)

Assessment was performed through visual analogue scale (VAS). A visual analogue scale (VAS) of 100 mm was used as a self-rating of volunteers DOMS intensity, with assistance of a blinded researcher, where "0" corresponds to no pain and 100mm corresponds to the worst pain possible.

Time frame: 1 minute, 1 hour, 24 and 48 hours after the end of exercise protocol.

Biochemical marker of muscle damage

Analysis of Creatine Kinase (CK) levels

Time frame: 1 minute, 1 hour, 24 and 48 hours after the end of exercise protocol.

Data from ClinicalTrials.gov

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