Nutrient Mixtures and Neurodevelopment

N/ACompletedNCT03420872

Icahn School of Medicine at Mount Sinai329 enrolled

Overview

Background: Adequate levels of beneficial nutrients are important for neurodevelopment. Although, nutrients are ingested in combination, considering nutrients as a mixture has not been studied with respect to health, such as neurodevelopment. Objective: To examine the impact of prenatal and childhood nutrition mixtures on neurodevelopment. Design: Participants included mother-child pairs in the Programming Research in Obesity, Growth Environment and Social Stress (PROGRESS) prospective birth cohort in Mexico City. Prenatal and child nutrition profiles were assessed among 65 and 329 children respectively by analyzing components of a food frequency questionnaire. Child neurodevelopmental outcomes at 4-6 years of age were measured using the McCarthy Scales of Children's Abilities (MSCA).

Study Type

OBSERVATIONAL

Enrollment

329

Conditions

Neurodevelopment

Interventions

Nutrient mixturesOTHER

consumption of a mixture of beneficial nutrients

Eligibility

Medical Language ↔ Plain English

Inclusion Criteria: Women of children: * less than 20 weeks gestation at the start of the study * at least 18 years of age * and planned to reside in Mexico City for the next three years. Exclusion Criteria: Women of children: * free of heart or kidney disease * not use steroids or anti-epilepsy drugs * not consume alcohol.

Outcomes

Primary Outcomes

McCarthy Scales of Children's Abilities (MSCA)

The MSCA consists of 18 short sub-tests that are weighted and combined to yield five scale scores or indexes - verbal, perceptual performance, quantitative, memory and motor - as well as an overall general cognitive index based on the first three scaled indexes. The McCarthy Scale index scores can range from 22 - 78 with higher index scores indicating better outcome.

Time frame: at age 4