Intranasal esketamine, fentanyl and placebo are compared in treatment of acute pain in adult patients with minor trauma. Study is blinded randomized placebo-controlled parallel design.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
105
anesthetic used as analgetic in subanesthetic doses given intranasally
intravenous fentanyl given intranasally
intravenous saline given intranasally as placebo
Hyvinkää Hospital
Hyvinkää, Finland
RECRUITINGNumeric rating scale (NRS) change
Numeric rating scale is used to measure pain intensity. Scale is from 0-10. 0 = no pain, 10 = worst imegeable
Time frame: 15 minutes and 30 minutes
Amount of patients with NRS change more than -2
Amount of patients with NRS dropping more than 2 at time poin 15 minutes, 20 minutes and 60 minutes
Time frame: 15 min, 30 min, 60 min
Patient satisfaction (pain management)
Whole experience of pain management on NRS scale from 0-10 (0 = absolutely terrible, 10 = best imagenable)
Time frame: 120 min
Side effects
Time frame: 120 min
Amount of study drug consumed (doses)
Amount of sturdy drug consumed as doses in the end of study period. One dose is determined by patient weight.
Time frame: 120 min
Need for rescue medication mg (oxycodone)
Amount of oral or intramuscular oxycodone consumption in the end of study period as milligrams
Time frame: 120 min
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