Ethnic/Racial Differences in Metabolism and DNA Adduct Formation

Inclusion Criteria: * One of the three targeted ethnic groups: * Japanese American - two parents of Japanese descent * Non-Hispanic Whites - two parents of non-Hispanic white descent * Native Hawaiians will include individuals with at least one parent of Hawaiian descent; * Smoke 5 cigarettes per day over the past three months; * \>21 years of age; * Consumes 14 or fewer drinks of alcohol per week; * Generally stable and good health (determined by review of medical history); * Able to provide written voluntary consent before performance of any study related procedure. Exclusion Criteria: * Current use of other nicotine containing products for \> 4 times per month (and no use of any nicotine-containing products except cigarettes for 2 weeks prior to their study visits); * Acute or uncontrolled medical or psychiatric conditions; * Currently taking any medications that affect relevant metabolic enzymes or anti- inflammatory medications such as ibuprofen (this will be reviewed by study investigators on a case-by-case basis); * Active infection (e.g., influenza, cold, respiratory infection, sinus infection) at the time of the visit; * Pregnant or nursing or planning on becoming pregnant during the study; * Unable to read and understand English.