Study of Rotatory Vestibular Tests in Major Depression Patients and Healthy Control Subjects.

Vest Brain,Centro de Estudios Neurovestibulares41 enrolled

Overview

This study evaluates the vestibular activity in major depression patients and healthy controls using the rotatory test and electronystagmography.

Previous studies showed abnormal vestibular activity in major depression patients using caloric vestibular tests. The present study investigates the vestibular response to vestibular rotatory tests in major depression subjects and healthy controls.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Depression Vestibular Disorder

Interventions

Rotatory vestibular testDIAGNOSTIC_TEST

We will measure Depression and Healthy subjects vestibular activity by Rotatory Vestibular tests

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * male and females adults (18 years or older) * met the Diagnosing and Statistical Manual of Mental Disorders (DSM-IV-R, American Psychiatric Association, 2000) criterion. * had a score of 12 or more in the Hamilton Rating Scale, 21 items for Depression. * with or without actual pharmacological treatment, except benzodiazepines that were suspended 24 hours before the rotary test when corresponding. Exclusion Criteria: * pregnant women * neurologic disorders.

Outcomes

Primary Outcomes

Vestibular Activity

The primary outcome corresponds to the vestibular activity. The vestibular stimulation provided by the rotatory chair is sensed by the inner ear´s vestibular receptors and generates reflex ocular movements(Vestibulo Ocular Reflex) registrated by electronystagmography. The main outcome corresponds to the asymmetry of the vestibular activity between both ears.

Time frame: Vestibular rotatory test for each participant is about 50- 60 minutes. One rotatory test per participant.

Data from ClinicalTrials.gov

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