Population Pharmacokinetics and Clinical Individual Dosage Regimen of Propofoll Injection

Inclusion Criteria: * patients aged 18-60 years (including those aged 18 and 60) who underwent gastrointestinal endoscopy; * weight should not be less than (≥) 50kg, not more than (≤) 80kg. Body mass index (BMI) = body weight kg / \[(height m) 2\], in the normal range of 19 to 25; * American Society of Anesthesiologists (ASA) grading (Appendix I): I or II; * no heart, liver, lung, kidney, digestive tract, nervous system, mental disorders and other medical history, no blood and metabolic diseases and other medical history, no potential difficulties airway and special past history, * blood, urine, stool routine, liver and kidney function, blood lipids, ECG, chest X-ray and blood pressure normal, or abnormal but no clinical significance, the researchers believe that can be grouped. * agree and sign informed consent. Exclusion Criteria: * important organs have primary disease; * persons with mental or physical disabilities; * those suffering from neurological or mental illness, a history of epilepsy; * patients with cardiovascular or respiratory insufficiency and hypovolemia; * obese or those with dyslipidemia; * hereditary acute porphyria; * infections, especially those with respiratory and central infections; * language exchange barriers; * suspected or indeed a history of alcohol, drug abuse; especially long-term use of non-steroidal anti-inflammatory drugs, opioids, tranquilizers; * allergies, if the history of drugs or food allergies; or known to propofol, soybeans, peanuts, coconut oil allergy; * smoking history (smoking ≥ 5 per day); * 2 weeks before the trial had used all kinds of Chinese and Western medicine; * the last 3 months of blood donors and test blood donors; * other circumstances that the researcher thinks can not be grouped (eg, frail, etc.).