Hypoglycemia and Autonomic Nervous System Function- B2

Inclusion Criteria: * Males and females age 18 to 55 years * Type 2 Diabetes Mellitus controlled by diet, exercise and non-insulin glycemic control agents (metformin, thiazolidinediones, sulfonylureas, dipeptidyl peptidase-4 inhibitors, sodium-glucose co-transporter 2 inhibitors, alpha-glucosidase inhibitors or glucagon-like peptide-1 receptor agonist) or basal insulin at doses less than or equal to 0.3 units/ kg per day. Exclusion Criteria: * Hemoglobin A1c \> 9% for type 2 diabetes * Recurrent hypoglycemic episodes within the past month * BMI \< 25 or \> 42 (Type 2 diabetes only) * Pregnancy * Lactation * Clinically significant coronary artery, cerebrovascular, or peripheral vascular disease, or presence of systemic illness that might affect autonomic function. Such illnesses include congestive heart failure, renal, pulmonary, hepatic disease, anemia, malignancies, untreated thyroid disease, and alcoholism. * Current major depressive illness * In all subjects, any individuals on oral, injected, inhaled or topical corticosteroids within the last year or oral contraceptives within the past 3 months will be excluded. * Known hypersensitivity to nitroglycerin, nitroprusside and/or phenylephrine. * Blood pressure \> 160/100 mmHg (applies to participants with T2 diabetes) * Creatinine \> 1.5 mg/dL * Serum potassium \>5.2 mmol/L * Estimated GFR \< 50 mL/min * Use of Viagra, Cialis, and similar drugs within 72 hours of admission. * Use of beta-blockers or mineralocorticoid receptor antagonists