Dietary Fibre and Metabolic Benefits

Lund University18 enrolled

Overview

The aim of the project is to study the connection between bacterial fermentation in the colon of prebiotic substrates and effects on systemic metabolism and appetite i healthy humans

The purpose with this project is to study the association between bacterial fermentation in the colon of specific mixtures of cereal dietary fiber and effects on systemic metabolism and appetite regulation. For this purpose, short term studies are performed in healthy adult subjects. Different cereals, cereal blends and from cereal extracted dietary fiber will be studied, as well as effects of different processing of the cereals. Cardiometabolic test markers and colonic fermentation metabolites will be followed up to 14 h after intake of the test substrates, and gut microbiota composition will be determined prior to and after the interventions.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

Conditions

Glucose Tolerance

Interventions

Cereal product 1OTHER

Cereal products based on rye, barley, wheat, oat, and corn

Cereal product 2OTHER

Cereal products based on rye, barley, wheat, oat, and corn

Cereal product 3OTHER

Cereal products based on rye, barley, wheat, oat, and corn

Eligibility

Sex: ALLMin age: 20 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * healthy adults * BMI\<30 * non smokers * consuming a non-vegetarian diet that follows the Nordic guidances Exclusion Criteria: * fasting blood glucose \>6.1 mmol/L * known cardio-metabolic disease (e.g. diabetes, hypertension, metabolic syndrome), gastro-intestinal disorders such as IBS (irritable bowel syndrome) that can interfere with the study results, food allergies. Further no antibiotics or probiotics should have been consumed within 4 weeks prior to and during the study.

Locations (1)

Food Technology, engineering and Nutrition, LTH, Lund University

Lund, Sweden

Outcomes

Primary Outcomes

Blood glucose regulation

Postprandial blood glucose regulation (incremental area under the curve) acute after intake of the test products and at forthcoming meals within 14 h after consumption of test products.