Small Airway Obstruction in Asthma, COPD, ACOS

Mahidol University230 enrolled

Overview

This study was designed as retrospective chart review to test our hypothesis whether there are the differences in inflammatory and anti-inflammatory mediators between asthmatic and ACOS patients with small airway obstruction, and COPD

The data including spirometry, lung volume, impulse oscillometry, sputum data, demographic characters within 6 months are collected for later analysis. Sputum supernatants and cytospins are used to determine inflammatory and anti-inflammatory responses in those patients.

Study Type

OBSERVATIONAL

Enrollment

230

Conditions

Asthma COPD Asthma-COPD Overlap Syndrome

Interventions

No any interventionOTHER

No any intervention is applied to any groups in this study

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Physician-diagnosed asthma, ACO, and COPD * Their spirometric, IOS, lung volume, demographic data and sputum samples are available Exclusion Criteria: * Concomitant diseases requiring immunosuppressive therapy * Being on treatments with NSAIDs, macrolides, statins

Locations (1)

Siriraj Hospital

Bangkok Noi, Bangkok, Thailand

Outcomes

Primary Outcomes

Lipoxin A4, ,

Lipoxin A4 is measured in sputum supernatants by ELISA

Time frame: 1 day (single time point)

Secondary Outcomes

IL-33

IL-33 is measured in sputum supernatants by ELISA

Time frame: 1 day (single time point)

Thymic stromal lymphopoietin (TSLP)

TSLP is measured in sputum supernatants by ELISA

Time frame: 1 day (single time point)

Data from ClinicalTrials.gov

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