Cardiovascular Clinical Project to Evaluate the Regenerative Capacity of CardioCell in Patients With No-option Critical Limb Ischemia (N-O CLI)

Inclusion Criteria: * Patients able to walk * Male and female patients, aged 18-80 years * No-option CLI (definition: exhausted revascularization options including surgery or endovascular treatment) in Rutherford stage 4-5 * In case of bilateral N-O CLI, the limb with shorter claudication distance will be treated * Presence of adequate inflow (patent iliac and common femoral arteries) * Run-off through at least one (even partially seen) below-the-knee (BTK) artery * Signed informed consent Exclusion Criteria: * Malignancy * Moderate or severe immunodeficiency * Acute or chronic bacterial or viral infectious disease * Soft tissue disease or local infection in a place of required artery puncture * Pregnancy or breastfeeding * Any objective or subjective reason for inability to attend follow-up visits * Females of childbearing potential, who does not want to use a highly effective method of contraception * Females of childbearing potential who does not have a menstrual period confirmed and a negative highly sensitive urine or serum pregnancy test * Participation in any other clinical research study that has not reached the primary efficacy endpoint or otherwise would interfere with the patient's participation in this project * Life expectancy \< 1 year * Any concurrent disease or condition that, in the opinion of the investigator, would make the patient unsuitable for participation in the project