The purpose of this study is to determine the effects of dietary salt restriction on central hemodynamics and vascular function in men and women with salt resistant blood pressure.
Cardiovascular disease remains a major Public Health problem and is the leading cause of death in the US. Dietary sodium restriction is considered an important lifestyle modification for individuals with hypertension; however, there is controversy about the effects of dietary salt given that many individuals do not have "salt sensitive" blood pressure. Deleterious effects of salt on the vasculature may explain the finding that chronic DSR reduces the cardiovascular event rate by 25%despite only minor reductions in BP. It is not known whether dietary sodium restriction improves central pulsatile hemodynamics, known to be related to the development of left ventricular hypertrophy and heart failure risk, and whether the hypothesized improvements in central hemodynamics are similar in men \& women. The purpose of this study is to determine the effects of dietary sodium restriction through dietary counseling on central hemodynamics and vascular function in men and women with salt resistant blood pressure.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
100
A registered dietician will counsel participants to reduce daily habitual dietary salt intake below 2000mg over 4 weeks
Participants will consume their routine habitual dietary sodium intake \> 3400mg per day with regular pre determined check in phone calls from a registered dietician.
Department of Kinesiology and Applied Physiology, University of Delaware
Newark, Delaware, United States
Reflected Pulse Wave Amplitude
Late systolic pulsatile load on the left ventricle represented by reflected pulse wave amplitude; assessed by echocardiography combined with applanation tonometry.
Time frame: Change from baseline at 4 weeks
Microvascular Function
Cutaneous microvascular dilatory response to local heating assessed by laser Doppler flowmetry coupled with intradermal microdialysis
Time frame: Change from baseline at 4 weeks
Conduit Artery Endothelial Dependent Dilation
Brachial artery flow mediated dilation assessed by duplex ultrasound
Time frame: Change from baseline at 4 weeks
Arterial Stiffness
Carotid - Femoral pulse wave velocity assessed by applanation tonometry
Time frame: Change from baseline at 4 weeks
Forward pulse wave amplitude
Central hemodynamic assessment of the forward pulse wave amplitude assessed by echocardiography combined with applanation tonometry.
Time frame: Change from baseline at 4 weeks
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