Glucose Absorption and Gut Hormone Secretion After Gastric Bypass

Hvidovre University Hospital10 enrolled

Overview

To investigate the impact of canagliflozin on secretion of gut hormones, in particular glucagon-like peptide 1 (GLP-1) in gastric bypass operated patients.

Glucose is a potent stimulus for GLP-1 secretion after gastric bypass surgery and the SGLT-1 transporter appears to be crucial for this response. The study will investigate the effects of SGLT-1/SGLT-2 inhibition (by canagliflozin) on secretion of GLP-1 and other gut hormones after gastric bypass surgery.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Overweight

Interventions

GlucoseDIETARY_SUPPLEMENT

Ingestion of glucose (50 g) dissolved in 200 ml water.

Glucose + CanagliflozinDIETARY_SUPPLEMENT

Ingestion of glucose (50 g) dissolved in 200 ml water combined with the SGLT-1/SGLT-2 inhibitor canagliflozin.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: •Uncomplicated gastric bypass surgery performed minimum 12 months prior to study Exclusion Criteria: * Type 1 or 2 diabetes mellitus prior to or after gastric bypass surgery * Pregnancy or breastfeeding * Haemoglobin levels below 6,5 mM

Locations (1)

Dept. of Endocrinology

Hvidovre, Denmark

RECRUITING