A Randomized Study to Establish the Efficacy of Oral Ice Exposure During Oxaliplatin Infusion in Preventing Oral Cold Sensitivity

Inclusion Criteria: * Individuals ≥18 years of age will be enrolled. * Patients must have histologic confirmation of a solid tumor malignancy that will be treated with a regimen that contains full-dose oxaliplatin. * Patients may be receiving treatment in the neoadjuvant, adjuvant or metastatic setting. * Patients must be treatment-naïve to platinum-agents at the time of enrollment. Prior treatment with non-platinum agents is permitted. Exclusion Criteria: * Any active intraoral infection, including yeast infection (thrush) or active oral herpes simplex virus at the time of enrollment. * Patients may not have dentures. * Patients may not have a disorder that may result in altered taste sensation at baseline. This includes but is not limited to: persistent dry mouth.