Apatinib for Advanced Biliary Carcinoma

Inclusion Criteria: 1. Patients age between 18 and 70 years 2. Histologically confirmed advanced biliary tract carcinoma (BTC) or metastatic BTC 3. Prior lack of response or intolerance to at least one chemotherapeutic regimens (including gemcitabine). 4. At least one measurable lesion as defined by RECIST 1.1 5. An Eastern Cooperative Oncology Group performance status of 0 to 2 6. Life expectancy ≥ 12 weeks 7. For those who received other anti-tumor treatment, the damage should have been restored, with the time interval from last dose of nitroso or mitomycin≥6 weeks and interval from last dose of other cytotoxic drugs, radiation or surgery (the wound should be healed completely) ≥4 weeks. 8. Acceptable hematologic, hepatic, and renal function within 7 days from screening： the blood ANC count≥1.5x109 /L; hemoglobin ≥ 9.0 g/dl，the blood platelet count≥80 x109 /L, total bilirubin \< 1.5 x ULN, ALT and AST\< 2.5 x ULN(\< 5 x ULN for patients with live metastasis), serum creatinine≤1 x ULN，endogenous creatinine clearance rate \>50ml/min 9. Women of reproductive age need to take effective contraceptive measures Exclusion Criteria: 1. With other malignant tumor in 5 years，except for cured cervical carcinoma in situ or basal cell carcinoma. 2. Uncontrolled blood pressure on medication (140/90 mmHg); patients with \> Grade 1 coronary heart disease, cardiac arrhythmias or cardiac dysfunction 3. Symptomatic brain or meningeal metastasis 4. History of uncontrolled seizures, central nervous system dysfunction or mental disorder 5. Uncontrolled pleural or peritoneal effusion 6. Undergoing dialysis 7. Severe or uncontrolled infection 8. With multiple factors that affecting oral administration 9. Abnormal coagulation function or those receiving thrombolytics or anticoagulants 10. Patients with tendency of gastrointestinal hemorrhage, including active peptic ulcer with fecal occult blood ++, hematemesis or melena within 3 months 11. Participation in other drug clinical trials within 4 weeks 12. Weight below 40kg 13. urine protein ≥2+