Probiotics are live microorganisms exhibiting multiple properties beneficial to health. An increasing body of evidence indicates that probiotics may support healthy brain function and may relieve stress. Recent research in this area has examined lactic acid bacteria in detail, but little is known about the stress-relieving effects of Saccharomyces, a yeast with probiotic properties. Psychological stress is a factor that allows people to successfully cope with various daily life situations. On the other hand, excessive stress may lead to bodily harm and decrease performance, e.g. academic achievements. Probiotics may help manage stress, but little is known whether probiotics improve performance under stress. The aim of this trial is to examine whether the healthy medical students may demonstrate better performance in academic examinations when supplementing their diet with a yeast probiotic strain Saccharomyces boulardii (CNCM I-1079) or bacterial probiotic strain Lactobacillus rhamnosus GG (ATCC 53103). The secondary aim of the trial is to evaluate the potential effects of this supplementation on state anxiety as well as on biochemical and physiological stress markers.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
92
30 days of supplementation, 6x10\^9 CFU/day
30 days of supplementation, 5x10\^9 CFU/day
30 days of supplementation
Performance under examination-related stress
Number of correctly-answered questions in the final examination in Basic Medical Pharmacology
Time frame: The examination is held on the 30th day of the trial.
State anxiety under examination-related stress
State anxiety measured with State-Trait Anxiety Inventory (STAI)
Time frame: 30 minutes before the final examination in Basic Medical Pharmacology
Cortisol
Salivary cortisol level
Time frame: Measured a day before the final examination in Basic Medical Pharmacology
Pulse rate
Individual, instructed measurement of pulse rate
Time frame: 30 minutes before the final examination in Basic Medical Pharmacology
Metanephrine
Salivary metanephrine level
Time frame: Measured a day before the final examination in Basic Medical Pharmacology
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