A First In Human Study to Assess CiVi007 in Subjects With an Elevated LDL-Cholesterol Level

Key Inclusion Criteria: * Males or females, of any race, with fasting LDL C \>2.6 mmol/L (100 mg/dL) and fasting serum triglycerides \<4.52 mmol/L (400 mg/dL) * haematology and clinical chemistry without clinically significant abnormal values * Normal renal and hepatic function * Women must not be pregnant, lactating or of child bearing potential * Men must be willing to use appropriate contraception during the study * Able to comprehend and willing to sign an ICF and to abide by the study restrictions. Key Exclusion Criteria: * Any uncontrolled or serious disease, or any medical or surgical condition * History or presence of coronary heart disease, peripheral artery disease, or cerebrovascular disease * Uncontrolled hypertension * Insulin dependent diabetes mellitus * Secondary dyslipidemia * History of renal or hepatic diseases, acquired immune deficiency syndrome, positive human immunodeficiency virus test and/or history of viral hepatitis B or C * History of cancer within 5 years * History of high alcohol consumption or positive alcohol breath test or urinary test for drugs of abuse * Participation in another clinical study within 3 months prior to screening or participation in another study * Use of treatment (e.g. antibody) towards PCSK9 * History of multiple drug allergies or intolerance to subcutaneous injection.