Prophylaxis Versus Treatment for TURP Syndrome.

Ahmed Mohamed ELbadawy60 enrolled

Overview

This study is designed to investigate the usage \& effects of prophylactic HS preloading, with two different concentrations, to combat the expected dilutional hyponatremia induced by irrigating fluid absorption and to prevent the occurrence of TURP syndrome with its potential complications

The study will be conducted on 60 patients ASA class I - III BPH patients, candidates for TURP surgery using monopolar electronic resectoscope. Eligible patients will be allocated into one of three study groups (n=20 in each). Group A patients will receive NaCl 3% HS at a dose of 4 ml/kg/hr; Group B patients will receive NaCl 3% HS at a dose of 2 ml/kg/hr; while Group C patients will receive NaCl 0.9% Normal Saline(NS) at a dose of 6 ml/kg/hr. All intra-venous infusions will be started 30 minutes before the subarachnoid block, and continued all through the procedure at the same specific rate for each infusion. Vital signs \[mean BP, HR, CVP \& oxygen saturation (spO2)\] will be recorded. Plasma electrolytes (sodium, potassium, chloride)and serum osmolality (mOsm) will be measured. Incidence of TUR syndrome, need for ICU admission, post-operative ventilation and total hospital stay will be noted.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

Conditions

Transurethral Resection of Prostate Syndrome

Interventions

NaCl 3% HSDRUG

Hypertonic saline 3% is a type of crystalloid solution with osmolarity higher than that of plasma.

NaCl 3% HSDRUG

Hypertonic saline 3% is a type of crystalloid solutions with osmolarity higher than that of plasma.

NaCl 0.9% NSDRUG

Normal saline 0.9% is a type of crystalloid solution with osmolarity similar to that of plasma.

Eligibility

Sex: MALEMin age: 50 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ASA class I - III BPH patients Exclusion Criteria: * Patients having any condition contra-indicating regional anesthesia e.g impaired coagulation. * Electrolyte imbalance, * Uncontrolled hypertension, * Congestive heart failure or being allergic to local anesthetics.

Locations (1)

Faculty of Medicine

Cairo, Egypt

Outcomes

Primary Outcomes

Serum sodium level measured in mEq/L

Hyponatremia was defined as a serum sodium \< 130 mEq/L

Time frame: 72 hours

Secondary Outcomes

Incidence of TURP syndrome

Occurring TURP syndrome manifestations

Time frame: 72 hours

Need for ICU admission

For cardio-pulmonary support(vasopressor,mechanical ventilation), neurological monitoring

Time frame: 72 hours

Data from ClinicalTrials.gov

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