Effects of Intranasal Oxytocin on Functional Brain Network in Resting-state and Tasks

Beijing Normal University34 enrolled

Overview

To investigate whether and how intranasal oxytocin of 8IU treatment will alter the topology of functional brain network in resting-state and multiple tasks in healthy males.

In a randomized, double-blind, cross-over, placebo controlled design, healthy male volunteers receive intranasal oxytocin or placebo prior to functional magnetic resonance imaging.Subjects will then go through a decision making task, a emotion judgement task and an eight-minute resting-state scan in MRI scanner to investigate whether and how intranasal oxytocin alter the topology of functional brain network in resting-state and multiple tasks in healthy males. State anxiety and mood are measured before and after experiment as covariates to be controlled.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

Conditions

Healthy

Interventions

OxytocinDRUG

intranasally administrated

PlaceboDRUG

intranasally administrated

Eligibility

Sex: MALEMin age: 18 YearsMax age: 30 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * healthy subjects without past or current psychiatric or neurological disorders Exclusion Criteria: * with MRI Contraindications

Locations (1)

School of Brain and Cognitive Sciences, Beijing Nornal University

Beijing, Beijing Municipality, China

Outcomes

Primary Outcomes

Functional network organization alterations in brain under resting state fMRI after drug administration

Using seed-based and network level functional connectivity analysis, as well as graph theory analysis , functional network organization in brain under eight minutes resting state will be detected and compared between oxytocin and placebo group.

Time frame: 70~85 minutes after drug administration

Behavior,brain activities and representation patterns in the emotional judgement task after drug administration

Friend or Foe Task is used to measure the verbal versus nonverbal emotional judgement of subjects. Both the response of subjects and the brain activity are recorded in the task. How oxytocin influences the relationship between subjects' behavior and representation pattern of emotional judgement will be investigated through RSA(representation similarity analysis) of brain pattern.

Time frame: 60~75 minutes after drug administration

Behavior, dynamics brain activities and networks in the model-based decision making task after drug administration

Two-Stage Decision Making Task is used to measure the model-based and model-free decision making process of subjects. The degree of model-based will be calculated by Computational modelling of Subjects' decision making process, and entering as modulation parameter in the OT effect on dynamic brain seed-based and network-based connectivity pattern.

Time frame: 35~60 minutes after drug administration

Relationship of functional network organization in brain across resting state and task-based fMRI after drug administration

The functional brain activity in resting state, emotional judgement and decision making task will be compared. Both the functional segregation and integration will be measured using graph theory and network connectivity analysis to discover the OT effect on brain network organization across multiple cognitive states.

Time frame: 60~85 minutes after drug administration

Data from ClinicalTrials.gov

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