Emotion Regulation in Binge Eating and Purging Among Adolescents

Stanford University47 enrolled

Overview

The study will examine the neural and behavioral correlates of emotion regulation in adolescents engaging in binge eating and/or purging and healthy adolescents. Furthermore, it will look at the influence of executive function on emotion regulation in this population. This study will allow us to gain further understanding of the neural basis of emotion regulation in this age group. Moreover, this study supports the need to develop new treatment approaches based on a better understanding of the brain processes associated with eating disorders.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Binge Eating Purging (Eating Disorders)

Interventions

Magnetic resonance imagingOTHER

We will conduct MRI and fMRI brain scans to compare brain function between groups.

Eligibility

Sex: FEMALEMin age: 14 YearsMax age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Female * Ages 14-18 * with or without current binge eating and/or purging behaviors Exclusion Criteria: We exclude patients of clinically significant low weight (\<85% ideal body weight using CDC norms for height, age, and gender) and those with contraindications for MRI (e.g., orthodontia, metallic implants). Participants also will be without evidence of current or past major neurological (e.g., seizures, psychosis, head trauma) or major sensory deficit.

Locations (1)

Stanford University, Department of Psychiatry

Stanford, California, United States

Outcomes

Primary Outcomes

Brain activity during emotion conflict

Functional magnetic resonance imaging will be used to measure brain activity during a task where participants respond to images of faces with emotional expressions overlaid with an emotion word written in text. We will focus on brain response during this task when emotion face vs word are in conflict.

Time frame: Baseline

Brain activity during emotion regulation

Functional magnetic resonance imaging will be used to measure brain activity during a task where participants attempt to regulate emotional responses.

Time frame: Baseline

Brain activity during cognitive control and emotion response

Functional magnetic resonance imaging will be used to measure brain activity during a task where participants engage in cognitive control and respond to emotional stimuli.

Time frame: Baseline

Secondary Outcomes

Behavioral performance on emotion conflict task

Response times will be used as behavioral measure on the emotion conflict task

Time frame: Baseline

Behavioral performance on emotion regulation task

Emotion ratings will be used as behavioral measure on the emotion regulation task

Time frame: Baseline

Behavioral performance on cognitive control and emotion regulation task

Emotion ratings will be used as behavioral measure on the cognitive control and emotion regulation task

Time frame: Baseline

Data from ClinicalTrials.gov

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