Lung Recruitment Maneuver as a Potential Predictor of Fluid Responsiveness in Mechanically Ventilated Pediatric Patients

Boston Children's Hospital48 enrolled

Overview

In this research study we want to learn more about using non-invasive tools as a way to predict whether or not a child under general anesthesia will require and respond to fluid administration. It is important for an anesthesiologist to know if a child would respond to fluid administration so that they can provide the optimal intervention for low blood pressure and avoid unnecessary treatment.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Anesthesia Intravenous Fluid Blood Pressure

Interventions

Eligibility

Sex: ALLMax age: 17 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 0 to \< 18 years old * Undergoing surgery at Boston Children's Hospital under general anesthesia * mechanically ventilated with an endotracheal tube * Monitored with an indwelling radial arterial catheter as part of the anesthetic plan for the scheduled surgical procedure Exclusion Criteria: * Prematurity * Low birth weight * Congenital heart disease * Left or right ventricular dysfunction * Cardiac arrhythmia * Pulmonary hypertension * Preoperative parenchymal or interstitial lung disease * Intracranial hypertension * Poor transthoracic acoustic window * Obesity * Allergy to ultrasound transmission gel * Need for single lung ventilation * Systemic hypertension on antihypertensive medications

Outcomes

Primary Outcomes

Change in stroke volume

Evaluate Lung Recruitment Maneuver as a means to predict fluid responsiveness in mechanically ventilated pediatric patients in the operating room.

Time frame: immediately before and after each intervention

Secondary Outcomes

Change in arterial compliance effect on Systolic Pressure Variation (mmHg)

Evaluate the effect of arterial stiffness on Systolic Pressure Variation (mmHg) in mechanically ventilated pediatric patients in the operating room.

Time frame: immediately before and after each intervention

Change in arterial compliance effect on Pulse Pressure Variation (%)

Evaluate the effect of arterial stiffness on Pulse Pressure Variation (%) in mechanically ventilated pediatric patients in the operating room.

Time frame: immediately before and after each intervention

Change in arterial compliance effect on Plethysmographic Variability Index (%)

Evaluate the effect of arterial stiffness on Plethysmographic Variability Index (%) in mechanically ventilated pediatric patients in the operating room.

Time frame: immediately before and after each intervention

Lung Recruitment Maneuver as a Potential Predictor of Fluid Responsiveness in Mechanically Ventilated Pediatric Patients

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes

Central Contacts