The aim of this randomized trial was to assess the efficacy of oral midodrine tablets for the management of intradialytic hypotension among critically ill patients with acute kidney injury.
In This open -label study, patients in ICU with acute kidney injury are randomized to either midodrine tablets or placebo. the number of intradialytic episodes and both systolic and diastolic blood pressure between both groups are compared. Mortality and adverse effects are monitored and compared as well.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
80
Number of hypotensive episodes
Number of hypotensive episodes
Time frame: 30 days from start of hemodialysis
mean systolic blood pressure
compare mean systolic blood pressure between the two arms
Time frame: 30 days from start of hemodialysis
mean diastolic blood pressure
compare mean diastolic blood pressure between the two arms
Time frame: 30 days from start of hemodialysis
Mortality in each arm
Number of dead patients in each arm
Time frame: 30 days from start of hemodialysis
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