The aim of the study is to investigate sleep apnea, circulation and metabolism in acromegaly before and after surgery and/or medical treatment.
Acromegaly is a rare disease caused by a growth hormone (GH) producing pituitary adenoma. Surgery is primary treatment, whereas medical treatment with a somatostatin analogue (SA), which suppresses GH secretion and reduces tumour size, is used when surgery is insufficient or unfeasible. Acromegaly is associated with metabolic abnormalities which contributes to an increased morbidity and mortality if left untreated. To which extend these abnormalities reverses after treatment, and if treatment modality influences the outcome, remain elusive. The aim of the study is to investigate sleep apnea, circulation and metabolism in acromegaly before and after surgery and/or medical treatment
Study Type
OBSERVATIONAL
Enrollment
20
Aarhus University Hospital, Department of internal medicine and endocrinologi
Aarhus, Denmark
RECRUITINGSleep apnea
ApneaLinkAir: respiratory effort, puls, oxygen saturation, nasal flow and snoring
Time frame: At baseline (time of diagnosis) and at an average of 1 years treatment
Circulation
Sphygmocor: central arterial pressure and pulse wave velocity
Time frame: At baseline (time of diagnosis) and at an average of 1 years treatment
Bone metabolism
HRpQCT scan
Time frame: At baseline (time of diagnosis) and at an average of 1 years treatment
Heartfunction
Echocardiography
Time frame: At baseline (time of diagnosis) and at an average of 1 years treatment
Substrate metabolism; signaling proteins
Western blotting
Time frame: At baseline (time of diagnosis) and at an average of 1 years treatment
Substrate metabolism; gene targets
qPCR
Time frame: At baseline (time of diagnosis) and at an average of 1 years treatment
Energy expenditure
Indirect calorimetry
Time frame: At baseline (time of diagnosis) and at an average of 1 years treatment
Body composition
DXA scan
Time frame: At baseline (time of diagnosis) and at an average of 1 years treatment
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Physical activity
Sensoriband
Time frame: At baseline (time of diagnosis) and at an average of 1 years treatment