The investigators aim to investigate the impact of thoracic radiation therapy on diffusion capacity of the lung (primary endpoint: diffusion capacity for nitric oxide, DLNO) and on exhaled nitric oxide.
Study Type
OBSERVATIONAL
Enrollment
3
University Hospital of Zurich
Zurich, Switzerland
Change in diffusing capacity for nitric oxide (DLNO)
Time frame: Before start of radiation therapy (RT), at the day of end of RT, 6 weeks and 12 months after end of RT
Diffusing capacity for carbon monoxide (DLCO)
The course over time will be described.
Time frame: Before start of radiation therapy (RT), at the day of end of RT, 6 weeks and 12 months after end of RT
Transfer Coefficient for nitric oxide (DLNO/VA)
The course over time will be described.
Time frame: Before start of radiation therapy (RT), at the day of end of RT, 6 weeks and 12 months after end of RT
Transfer Coefficient for carbon monoxide (DLCO/VA)
The course over time will be described.
Time frame: Before start of radiation therapy (RT), at the day of end of RT, 6 weeks and 12 months after end of RT
Ratio of DLNO and DLCO
The course over time will be described.
Time frame: Before start of radiation therapy (RT), at the day of end of RT, 6 weeks and 12 months after end of RT
Alveolar-capillary membrane-diffusing capacity for carbon monoxide (DMCO)
The course over time will be described.
Time frame: Before start of radiation therapy (RT), at the day of end of RT, 6 weeks and 12 months after end of RT
Pulmonary capillary blood volume (Vc)
This variable is a calculated variable. The course over time will be described.
Time frame: Before start of radiation therapy (RT), at the day of end of RT, 6 weeks and 12 months after end of RT
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Alveolar Volume (VA)
This variable is a calculated variable. The course over time will be described.
Time frame: Before start of radiation therapy (RT), at the day of end of RT, 6 weeks and 12 months after end of RT
Fractional concentration of exhaled nitric oxide at a flow rate of 50mL/s (FENO50)
The course over time will be described.
Time frame: Before start of radiation therapy (RT), at the day of end of RT, 6 weeks and 12 months after end of RT
Concentration of nitric oxide in the gas phase of the alveolar or acinar region (CANO)
The course over time will be described.
Time frame: Before start of radiation therapy (RT), at the day of end of RT, 6 weeks and 12 months after end of RT
Tissue concentration of nitric oxide of the airway wall (CawNO)
The course over time will be described.
Time frame: Before start of radiation therapy (RT), at the day of end of RT, 6 weeks and 12 months after end of RT
Airway compartment diffusing capacity of nitric oxide from the of of the airway wall to the gas stream (DawNO)
The course over time will be described.
Time frame: Before start of radiation therapy (RT), at the day of end of RT, 6 weeks and 12 months after end of RT
Total flux of nitric oxide in the conducting airway compartment (JawNO)
The course over time will be described.
Time frame: Before start of radiation therapy (RT), at the day of end of RT, 6 weeks and 12 months after end of RT
Forced expiratory volume in 1 second
The course over time will be described.
Time frame: Before start of radiation therapy (RT), at the day of end of RT, 6 weeks and 12 months after end of RT
Forced vital capacity
The course over time will be described.
Time frame: Before start of radiation therapy (RT), at the day of end of RT, 6 weeks and 12 months after end of RT
Forced expiratory flow between 25% and 75% of forced vital capacity
The course over time will be described.
Time frame: Before start of radiation therapy (RT), at the day of end of RT, 6 weeks and 12 months after end of RT