Effective Fraction of Inspired Oxygen With Nasal Cannula in Premature Infants

University of Miami35 enrolled

Overview

The objective of this study is to determine the multifactorial relationship between the effective fraction of inspired oxygen (Effective-FiO2) and the FiO2 in the gas delivered by the nasal cannula (NC-FiO2), NC flow rate, spontaneous minute ventilation and other patient characteristics in premature infants who receive supplemental oxygen via nasal cannula (NC).

During routine nasal cannula (NC) use in the newborn ICU, the actual fraction of oxygen inspired by the infant, i.e. the effective FiO2 (Effective-FiO2) that reaches the infant's airways, cannot be easily determined. The effective FiO2 during NC use is generally lower than the FiO2 in the gas delivered by NC at the infant's nose due to dilution with ambient gas entrained by the infants during spontaneous inspiration. The factors influencing effective FiO2 include the set FiO2 of the gas delivered by NC (NC-FiO2), the NC-flow rate, and the entrainment of ambient gas by the infant during each spontaneous inspiration. The individual contribution of each of these factors to the variability in effective-FiO2 in extreme premature infants has not been systematically evaluated. The objective of this study is to determine the multifactorial relationship between the effective fraction of inspired oxygen (Effective-FiO2) and the FiO2 in the gas delivered by the nasal cannula (NC-FiO2), NC flow rate, spontaneous minute ventilation and other patient characteristics in premature infants who receive supplemental oxygen via nasal cannula (NC).

Study Type

OBSERVATIONAL

Enrollment

Conditions

Oxygen Therapy

Interventions

Nasal cannula flow rateOTHER

This is a crossover study where observations will be obtained at five nasal cannula flow rates: 0.5, 1, 2, 4 and 6 liters per minute.

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Premature infants born between 23 and 30 weeks of gestational age * Receiving supplemental oxygen via nasal cannula * Parental informed consent Exclusion Criteria: * Major congenital anomalies * Clinically unstable

Locations (1)

NICU at Holtz Children's Hospital

Miami, Florida, United States

Outcomes

Primary Outcomes

Nasal cannula FiO2

FiO2 necessary to maintain the effective FiO2 (measured at the hypopharynx) at the basal level at different nasal cannula flow rates.

Time frame: from birth upto 40 weeks corrected postmenstrual age

Data from ClinicalTrials.gov

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