Effect of Fully Blocking Type 1 Angiotensin Receptor on Target Organ Damage of Postmenopausal Hypertensive Women

LanZhou University102 enrolled

Overview

This study compared the improvements of blood pressure levels, left ventricular hypertrophy, left ventricular diastolic function, vascular function and cognitive function between postmenopausal hypertensive women and age-matched hypertensive male patients through the evaluation of the effects of fully blocked AT1 receptor by valsartan. Additionally, the differences of the above indexes between the patients who were fully blocked AT1 receptor by valsartan and the patients who were treated with a single dose of valsartan treatment were assessed, so as to provide theory basis for clinical treatment of postmenopausal hypertensive women.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

102

Conditions

Hypertension

Interventions

Eligibility

Sex: ALLMin age: 40 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Clinical diagnosis of hypertension * Women are all postmenopausal * Must provide written informed consent Exclusion Criteria: * Secondary hypertension * Coronary disease * Heart failure * Arterial fibrillation * Previous myocardial infarction * Previous stroke * Malignant disease * Kidney failure * Liver failure * Neoplastic disease * Severe neurological diseases * Severe metabolic or organic decompensation * Refuse to sign the informed consent form

Outcomes

Primary Outcomes

Relative indexes of myocardial remodeling

Cardiac structure (left ventricular mass index in grams for square meter) measurement.

Time frame: Change from Baseline left ventricular mass index at 6 months.

Relative indexes of myocardial remodeling

Cardiac structure (left ventricular mass index in grams for square meter) measurement.

Time frame: Change from Baseline left ventricular mass index at 12 months.

Ambulatory blood pressure monitoring

Non-invasive ambulatory blood pressure monitoring (ABPM) was performed for every enrolled patient with an ABPM equipment.

Time frame: Change from Baseline ABPM at 6 months.

Ambulatory blood pressure monitoring

Non-invasive ambulatory blood pressure monitoring (ABPM) was performed for every enrolled patient with an ABPM equipment.

Time frame: Change from Baseline ABPM at 12 months.

Sexual hormones

Blood samples used to analyze the levels of sexual hormones were collected between morning 8:00 and 9:00 after an overnight fast. The sexual hormones which include prolactin (PRL) and progesterone (P) units on nanogram per millilitre, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) units on millionInternationalUnits per millilitre, testosterone (T) in nanogram per deciliter, estradiol (E2) in picogram per millilitre.

Time frame: Baseline sexual hormones.