Salivary Antioxidant Capacity Before and After Complete Dental Rehabilitation

Riyadh Colleges of Dentistry and Pharmacy40 enrolled

Overview

Salivary samples were obtained from 20 children in their fifth year of life diagnosed S-ECC and 20 age and sex matched controls. Complete dental rehabilitation under general anesthesia was performed for the 20 children with S-ECC, and follow up salivary samples were obtained one week and three months post operatively. The TAC was measured using a commercially available Oxygen Radical Absorbance Antioxidant Assay measurement kit (Zen-Bio ORAC™, AMS Biotechnology, Abington UK).

Background: The association of total salivary antioxidant capacity (TAC) to severe early childhood caries (S-ECC) has been studied in the past. It is not clear if TAC is an indicator of the inflammatory response to the lesion or a marker of the disease. Aim: This study aimed to measure the salivary TAC levels in children with early childhood caries before and after dental treatment and compare the results to caries free children. Methodology: Salivary samples were obtained from 20 children in their fifth year of life diagnosed S-ECC and 20 age and gendersex matched controls. Complete dental rehabilitation under general anesthesia was performed for the 20 children with S-ECC, and follow up salivary samples were obtained one week and three months post operatively. The TAC was measured using a commercially available Oxygen Radical Absorbance Antioxidant Assay measurement kit (Zen-Bio ORAC™, AMS Biotechnology, Abington UK).

Study Type

OBSERVATIONAL

Enrollment

Conditions

Dental Caries in Children

Interventions

Dental rehabilitation under general anesthesiaPROCEDURE

Dental treatment of all teeth affected by dental caries in a single visit under general anesthesia

Eligibility

Sex: ALLMin age: 60 MonthsMax age: 72 MonthsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Medically fit children * Age below 71 months * Test group - to be diagnosed with severe ECC * Control group - to be caries free Exclusion Criteria:

Locations (1)

Riyadh Colleges of Dentistry and Pharmacy

Riyadh, Saudi Arabia

Outcomes

Primary Outcomes

Change in TAC after one week

Change in Total Salivary Antioxidant Capacity of children from baseline to one week after treatment

Time frame: One week

Change in TAC after Three months

Change in Total Salivary Antioxidant Capacity of children from baseline to three months after treatment

Time frame: Three months

Data from ClinicalTrials.gov

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