This is a clinical trial to determine how effective antibiotics administered prior to endoscopic carpal tunnel release surgery are in preventing surgical site infections.
Study participants will be randomized to a prophylactic IV antibiotic treatment arm (Vancomycin or Cefazolin) or a placebo IV saline solution. Subjects will be monitored following surgery for surgical site infections.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
184
Vancomycin - 1-gram dosing
2-gram dosing for patients \<120 kg 3-gram dosing for patients 120 kg or greater
Placebo
WellSpan Surgery and Rehab Hospital
York, Pennsylvania, United States
Number of Participants With Surgical Site Infection
Definitive diagnosis of infection of surgical site -wounds determined to be infected will be divided into superficial or deep infections and treated according to the standard of care at WellSpan health.
Time frame: 2 weeks post-operative
Number of Participants With Surgical Site Infection
Definitive diagnosis of infection of surgical site -Definitive diagnosis of infection of surgical site -wounds determined to be infected will be divided into superficial or deep infections and treated according to the standard of care at WellSpan health.
Time frame: 6 weeks post-operative
Number of Participants With Diabetes Diagnosis and Surgical Site Infection
Number of patients with surgical site infection that have diabetes
Time frame: 2 weeks post-operative
Number of Participants With Diabetes Diagnosis and Surgical Site Infection
Number of patients with surgical site infection that have diabetes
Time frame: 6 weeks post-operative
Number of Participants With Surgical Site Infections That Use Tobacco
Number of patients with surgical site infections that use tobacco products
Time frame: 2 weeks post-operative
Number of Participants With Surgical Site Infections That Use Tobacco
Number of patients with surgical site infections that use tobacco products
Time frame: 6 weeks post-operative
Number of Participants With Chronic Obstructive Pulmonary Disease Diagnosis and Surgical Site Infection
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Number of patients with surgical site infections that have chronic obstructive pulmonary disease
Time frame: 2 weeks post-operative
Number of Participants With Chronic Obstructive Pulmonary Disease Diagnosis and Surgical Site Infection
Number of patients with surgical site infections that have chronic obstructive pulmonary disease
Time frame: 6 weeks post-operative
Number of Participants With Anemia Diagnosis and Surgical Site Infection
Number of patients with surgical site infections that have anemia
Time frame: 2 weeks post-operative
Number of Participants With Anemia Diagnosis and Surgical Site Infection
Number of patients with surgical site infections that have anemia
Time frame: 6 weeks post-operative
Number of Participants With Peripheral Artery Disease Diagnosis and Surgical Site Infection
Number of patients with surgical site infections that have peripheral artery disease
Time frame: 2 weeks post-operative
Number of Participants With Peripheral Artery Disease Diagnosis and Surgical Site Infection
Number of patients with surgical site infections that have peripheral artery disease
Time frame: 6 weeks post-operative
Number of Participants With Surgical Site Infection and a History of Arthroplasty
Number of patients with surgical site infections with history of arthroplasty
Time frame: 2 weeks post-operative
Number of Participants With Surgical Site Infection and History of Arthroplasty
Number of patients with surgical site infections with history of arthroplasty
Time frame: 6 weeks post-operative
Number of Participants With Valvular Disease Diagnosis and Surgical Site Infection
Number of patients with surgical site infections with valvular disease
Time frame: 2 weeks post-operative
Number of Participants With Valvular Disease Diagnosis and Surgical Site Infection
Number of patients with surgical site infections with valvular disease
Time frame: 6 weeks post-operative
Number of Participants With Surgical Site Infection That Underwent Single Incision Endoscopic Carpal Tunnel Release
Number of patients with surgical site infections with single incision ECTR
Time frame: 2 weeks post-operative
Number of Participants With Surgical Site Infection That Underwent Single Incision Endoscopic Carpal Tunnel Release
Number of patients with surgical site infections with single incision ECTR
Time frame: 6 weeks post-operative
Number of Participants With Surgical Site Infection That Underwent Double Incision Endoscopic Carpal Tunnel Release
Number of patients with surgical site infections with double incision ECTR
Time frame: 2 weeks post-operative
Number of Participants With Surgical Site Infection That Underwent Double Incision Endoscopic Carpal Tunnel Release
Number of patients with surgical site infections with double incision ECTR
Time frame: 6 weeks post-operative
Time From Last Cortisone Injection
For patients sustaining surgical site infection, the time from their last cortisone injection
Time frame: 2 weeks post-operative
Time From Last Cortisone Injection
For patients sustaining surgical site infection, the time from their last cortisone injection
Time frame: 6 weeks post-operative
Acuity of Carpal Tunnel Syndrome
For patients sustaining surgical site infection, the acuity of their carpal tunnel syndrome
Time frame: 2 weeks post-operative
Acuity of Carpal Tunnel Syndrome
For patients sustaining surgical site infection, the acuity of their carpal tunnel syndrome
Time frame: 6 weeks post-operative