Changes of Ocular Structures After Hemodialysis in Patients With Chronic Kidney Diseases

Hanyang University40 enrolled

Overview

To evaluate the effect of hemodialysis on various ophthalmologic parameters in patients with end-stage kidney disease (ESRD).

Subjects: patients with ESRD undergoing hemodialysis at the Dialysis Center of Hanyang Guri Hospital Ocular parameters: visual acuity, intraocular pressure, axial length, OCT Other systemic parameters: body weight, ultrafiltration volume, and systolic/diastolic blood pressure All measurements were performed near the dialysis center. Measurements were performed on Monday (for patients who underwent dialysis sessions on Monday, Wednesday, and Friday) or Tuesday (for patients who underwent dialysis sessions on Tuesday, Thursday, and Saturday. All parameters were measured before and after the hemodialysis.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Chronic Kidney Diseases Hemolysis

Interventions

ophthalmologic examsOTHER

ophthalmologic exams such as vision, intraocular pressure, axial length and optical coherence tomography

Eligibility

Sex: ALLMin age: 20 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 1\) patients who are regularly dialyzed in our dialysis room to participate in the study * 2\) patients who agree with our study protocol * 3\) patients who have unstable general condition Exclusion Criteria: * 1\) previous intraocular surgery, (2) baseline IOP greater than 22 mmHg, (3) presence of glaucomatous optic disc changes including excavation, thinning, or notching of the neuroretinal rim, (4) axial length greater than 26 mm, and (5) combined macular and retinal diseases such as central serous chorioretinopathy and age-related macular degeneration, except diabetic retinopathy.

Outcomes

Primary Outcomes

changes of retinal and choroidal thickness after hemodialysis

retinal \& choroidal thickness on OCT

Time frame: immediately (within 10 minutes) before and after hemodialysis

Secondary Outcomes

changes of foveal vascular density using optical coherence tomography-angiography (OCTA) after hemodialysis

vessel density on OCTA

Time frame: immediately (within 10 minutes) before and after hemodialysis

the effect of hemodialysis (HD) on anterior chamber angle by anterior segment optical coherence

intraocular pressure, retinal thickness, anterior chamber angle

Time frame: immediately (within 10 minutes) before and after hemodialysis

Data from ClinicalTrials.gov

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