Distinction Risk of Severe Infection in Febrile Neutropenia After Chemotherapy

University Hospital, Lille1,900 enrolled

Overview

Evaluate the reproducibility and validate a posteriori a new rule of clinical decision on a multi-center population of children with a post-chemotherapy febrile neutropenia

Study Type

OBSERVATIONAL

Enrollment

1,900

Conditions

Febrile Neutropenia, Rule of Clinical Decision, Chemotherapy

Eligibility

Sex: ALLMin age: 1 YearMax age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Child aged 1 to 18 years * Child with hematology or cancer * Child with a febrile neutropenia post-chemotherapy * Child with social security * No opposition from the child and/or parents, in case of absence, the holder of the parental authority present, can consent, alone, to the participation of the unemancipated minor. Exclusion Criteria: * Febrile neutropenia at diagnosis of tumor disease * Child with palliative care * Child having had a hematopoietic stem cell allo-graft in the preceding year * Febrile neutropenia immediately post auto-transplant * Antibiotherapy prior to admission * Initial care in a non-investigative center.

Locations (1)

Hôpital Jeanne de Flandre - CHRU de Lille

Lille, France

Outcomes

Primary Outcomes

Blood culture

Presence or not of bacteriemia

Time frame: On average between 5 days and 1 month

Positive bacterial culture from a normally sterile site

Presence or not of bacterial infection

Time frame: on average between 5 days and 1 month

microbiological culture

Presence or not of focal infection at high risk of dissemination was defined as any local infection with or without microbiological documentation into a normally sterile site, with significant risk of loco-regional or systemic spread

Time frame: On average between 5 days and 1 month

Fungal culture

Presence or not of fungal infection is referred to a proven, probable, or possible fungal infection as defined by the IFICG ot the EORTC

Time frame: On average between 5 days and 1 month

Data from ClinicalTrials.gov

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